Focal pulmonary abnormalities: Evaluation with F-18 fluorodeoxyglucose PET scanning

Edward F. Patz, Val J. Lowe, John M. Hoffman, Susan S. Paine, Paul Burrowes, R. Edward Coleman, Philip C. Goodman

Research output: Contribution to journalReview article

487 Scopus citations

Abstract

The authors assessed the role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in differentiation of benign from malignant focal pulmonary abnormalities seen on chest radiographs. Fifty-one patients underwent FDG PET scanning. Focal abnormalities at radiography included solitary pulmonary nodules (n = 38), pulmonary masses (n = 5), and poorly marginated infiltrates or opacities (n = 8). Proof of diagnosis was obtained by means of transbronchial biopsy (n = 21), open lung biopsy ( = 14), percutaneous needle biopsy (n = 14), or cytologic evaluation of sputum (n = 1). A nodule in one patient had been radiographically stable for at least 8 years. Quantitative analysis was performed by calculation of a standardized uptake ratio (SUR). Thirty-three malignant lesions had a mean SUR (± 1 standard deviation) of 6.5 ± 2.9. Eighteen benign lesions had a mean SUR of 1.7 ± 1.2. For a benign lesion with SUR of 2.5 or less, specificity of FDG PET was 100%, while sensitivity was 89%. These results suggest that FDG PET is accurate in differentiation of benign from malignant focal pulmonary abnormalities.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalRadiology
Volume188
Issue number2
DOIs
StatePublished - Aug 1993

Keywords

  • Emission CT (ECT), 610.12163
  • Fluorine
  • Lung neoplasms, diagnosis, 60.12163, 60.31, 60.321, 60.3221
  • Lung neoplasms, radionuclide studies, 60.12163
  • Lung, nodule, 60.28, 60.3221

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Patz, E. F., Lowe, V. J., Hoffman, J. M., Paine, S. S., Burrowes, P., Coleman, R. E., & Goodman, P. C. (1993). Focal pulmonary abnormalities: Evaluation with F-18 fluorodeoxyglucose PET scanning. Radiology, 188(2), 487-490. https://doi.org/10.1148/radiology.188.2.8327702