Focal hemosiderin deposits and β-amyloid load in the ADNI cohort

Kejal Kantarci, Jeffrey L. Gunter, Nirubol Tosakulwong, Stephen D. Weigand, Matthew S. Senjem, Ronald C. Petersen, Paul S. Aisen, William J. Jagust, Michael W. Weiner, Clifford R. Jack

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with 18F-florbetapir positron emission tomography. Results: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P <.001) and β-amyloid load (P <.001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P <.001). Conclusions: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.

Original languageEnglish (US)
Pages (from-to)S116-S123
JournalAlzheimer's and Dementia
Volume9
Issue number5 SUPPL.
DOIs
StatePublished - Oct 2013

Keywords

  • ADNI
  • Alzheimer's disease
  • Amyloid
  • Early mild cognitive impairment
  • Florbetapir
  • MRI
  • Microhemorrhage
  • Mild cognitive impairment
  • PET
  • Superficial siderosis

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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