Focal hemosiderin deposits and β-amyloid load in the ADNI cohort

Kejal M Kantarci, Jeffrey L. Gunter, Nirubol Tosakulwong, Stephen D. Weigand, Matthew S. Senjem, Ronald Carl Petersen, Paul S. Aisen, William J. Jagust, Michael W. Weiner, Clifford R Jr. Jack

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with 18F-florbetapir positron emission tomography. Results: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P <.001) and β-amyloid load (P <.001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P <.001). Conclusions: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
Volume9
Issue number5 SUPPL.
DOIs
StatePublished - Oct 2013

Fingerprint

Hemosiderin
Amyloid Plaques
Amyloid
Neuroimaging
Alzheimer Disease
Siderosis
Occipital Lobe
Positron-Emission Tomography
Cognitive Dysfunction

Keywords

  • ADNI
  • Alzheimer's disease
  • Amyloid
  • Early mild cognitive impairment
  • Florbetapir
  • Microhemorrhage
  • Mild cognitive impairment
  • MRI
  • PET
  • Superficial siderosis

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Focal hemosiderin deposits and β-amyloid load in the ADNI cohort. / Kantarci, Kejal M; Gunter, Jeffrey L.; Tosakulwong, Nirubol; Weigand, Stephen D.; Senjem, Matthew S.; Petersen, Ronald Carl; Aisen, Paul S.; Jagust, William J.; Weiner, Michael W.; Jack, Clifford R Jr.

In: Alzheimer's and Dementia, Vol. 9, No. 5 SUPPL., 10.2013.

Research output: Contribution to journalArticle

Kantarci, KM, Gunter, JL, Tosakulwong, N, Weigand, SD, Senjem, MS, Petersen, RC, Aisen, PS, Jagust, WJ, Weiner, MW & Jack, CRJ 2013, 'Focal hemosiderin deposits and β-amyloid load in the ADNI cohort', Alzheimer's and Dementia, vol. 9, no. 5 SUPPL.. https://doi.org/10.1016/j.jalz.2012.10.011
Kantarci, Kejal M ; Gunter, Jeffrey L. ; Tosakulwong, Nirubol ; Weigand, Stephen D. ; Senjem, Matthew S. ; Petersen, Ronald Carl ; Aisen, Paul S. ; Jagust, William J. ; Weiner, Michael W. ; Jack, Clifford R Jr. / Focal hemosiderin deposits and β-amyloid load in the ADNI cohort. In: Alzheimer's and Dementia. 2013 ; Vol. 9, No. 5 SUPPL.
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AU - Tosakulwong, Nirubol

AU - Weigand, Stephen D.

AU - Senjem, Matthew S.

AU - Petersen, Ronald Carl

AU - Aisen, Paul S.

AU - Jagust, William J.

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AU - Jack, Clifford R Jr.

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AB - Background: Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD). Methods: Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with 18F-florbetapir positron emission tomography. Results: Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P <.001) and β-amyloid load (P <.001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P <.001). Conclusions: Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.

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