Focal encephalitis following varicella-zoster virus reactivation without rash in a healthy immunized young adult

Geoffrey Halling, Caterina Giannini, Jeffrey W. Britton, Ricky W. Lee, Robert E. Watson, Christine L. Terrell, Ian F. Parney, Erin M. Buckingham, John E. Carpenter, Charles Grose

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Herein we describe an episode of focal varicella-zoster virus (VZV) encephalitis in a healthy young man with neither rash nor radicular pain. The symptoms began with headaches and seizures, after which magnetic resonance imaging detected a single hyperintense lesion in the left temporal lobe. Because of theprovisional diagnosis of a brain tumor, the lesionwas excised and submitted for pathological examination. No tumor was found. But the tissue immunostained positively for VZV antigens, and wild-type VZV sequences were detected. In short, this case represents VZV reactivation, most likely in the trigeminal ganglion, in the absence of clinical herpes zoster.

Original languageEnglish (US)
Pages (from-to)713-716
Number of pages4
JournalJournal of Infectious Diseases
Volume210
Issue number5
DOIs
StatePublished - Sep 1 2014

Keywords

  • Herpes zoster
  • Latency
  • Trigeminal ganglion
  • Valacyclovir
  • Varicella vaccine
  • Varicella-zoster virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Halling, G., Giannini, C., Britton, J. W., Lee, R. W., Watson, R. E., Terrell, C. L., Parney, I. F., Buckingham, E. M., Carpenter, J. E., & Grose, C. (2014). Focal encephalitis following varicella-zoster virus reactivation without rash in a healthy immunized young adult. Journal of Infectious Diseases, 210(5), 713-716. https://doi.org/10.1093/infdis/jiu137