Abstract
We have performed a prospective randomized controlled study of 5-fluorouracil (5FU) + leucovorin versus 5FU alone in patients with metastatic colorectal cancer. The 5FU at a dose of 370 mg/m2/d x 5 days and the leucovorin at a dose of 200 mg/m2/d x 5 days were given every 28 days. The 5FU dose was escalated to equitoxicity in the single agent arm on subsequent studies. The response rate was 33% for the combination and only 7% for 5FU alone. The median survival for 5FU + leucovorin was 12.6 months and 9.6 months for 5FU alone. The dose-limiting toxicity was mucositis with diarrhea being the second most common problem. The combination of 5FU + leucovorin is an effective treatment in the management of patients with metastatic colorectal cancer and should be used as a foundation from which to build upon.
Original language | English (US) |
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Pages (from-to) | 38-40 |
Number of pages | 3 |
Journal | Journal of chemotherapy (Florence, Italy) |
Volume | 2 Suppl 1 |
DOIs | |
State | Published - Feb 1990 |
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases