Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants

Keith Anthony Josephs, Joseph R. Duffy, Tepanta R. Fossett, Edythe A. Strand, Daniel O. Claassen, Jennifer Lynn Whitwell, Patrick J. Peller

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Objectives: To determine patterns of hypometabolism on fluorodeoxyglucose F18 positron emission tomography (FDG-PET) in patients with progressive apraxia of speech (PAS) and primary progressive aphasia (PPA) variants and to use these patterns to further refine current classification. Design: We identified all patients who had FDG-PET and PAS or PPA who were evaluated by an expert speech-language pathologist. Patterns of hypometabolism were independently classified by 2 raters blinded to clinical data. Three speech-language pathologists reclassified all patients into 1 of 7 operationally defined categories of PAS and PPA blinded to FDG-PET data. Setting: Tertiary care medical center. Patients: Twenty-four patients with PAS or PPA and FDG-PET. Main Outcome Measure: Fluorodeoxyglucose F18 PET hypometabolic pattern. Results: Of the 24 patients in the study, 9 had nonfluent speech output; 14, fluent speech; and 1 was unclassifiable. Twenty-one patients showed FDG hypometabolism; the remaining 3 did not. Among the patients showing hypometabolism, 8 had a prerolandic pattern of which 7 had nonfluent speech including progressive nonfluent aphasia (n=3), PAS (n=1), and mixed nonfluent aphasia/ apraxia of speech (n=3); the other patient had PPA unclassifiable. The remaining 13 had a postrolandic pattern, all with fluent speech (P<.001), including logopenic progressive aphasia (n=6), progressive fluent aphasia (n=6), and semantic dementia (n=1). Patterns of hypometabolism differed between the nonfluent variants and between the fluent variants, including progressive fluent aphasia. Conclusion: Patterns of FDG-PET hypometabolism support the clinical categorizations of fluency, the distinction of apraxia ofspeechfromprogressivenonfluentaphasia,and the designation of a progressive fluent aphasia category.

Original languageEnglish (US)
Pages (from-to)596-605
Number of pages10
JournalArchives of Neurology
Volume67
Issue number5
DOIs
StatePublished - May 2010

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Primary Progressive Aphasia
Apraxias
Fluorodeoxyglucose F18
Positron-Emission Tomography
Aphasia
Wernicke Aphasia
Positron Emission Tomography
Apraxia of Speech
Primary Progressive Nonfluent Aphasia
Language
Broca Aphasia
Frontotemporal Dementia
Tertiary Care Centers

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants. / Josephs, Keith Anthony; Duffy, Joseph R.; Fossett, Tepanta R.; Strand, Edythe A.; Claassen, Daniel O.; Whitwell, Jennifer Lynn; Peller, Patrick J.

In: Archives of Neurology, Vol. 67, No. 5, 05.2010, p. 596-605.

Research output: Contribution to journalArticle

Josephs, Keith Anthony ; Duffy, Joseph R. ; Fossett, Tepanta R. ; Strand, Edythe A. ; Claassen, Daniel O. ; Whitwell, Jennifer Lynn ; Peller, Patrick J. / Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants. In: Archives of Neurology. 2010 ; Vol. 67, No. 5. pp. 596-605.
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abstract = "Objectives: To determine patterns of hypometabolism on fluorodeoxyglucose F18 positron emission tomography (FDG-PET) in patients with progressive apraxia of speech (PAS) and primary progressive aphasia (PPA) variants and to use these patterns to further refine current classification. Design: We identified all patients who had FDG-PET and PAS or PPA who were evaluated by an expert speech-language pathologist. Patterns of hypometabolism were independently classified by 2 raters blinded to clinical data. Three speech-language pathologists reclassified all patients into 1 of 7 operationally defined categories of PAS and PPA blinded to FDG-PET data. Setting: Tertiary care medical center. Patients: Twenty-four patients with PAS or PPA and FDG-PET. Main Outcome Measure: Fluorodeoxyglucose F18 PET hypometabolic pattern. Results: Of the 24 patients in the study, 9 had nonfluent speech output; 14, fluent speech; and 1 was unclassifiable. Twenty-one patients showed FDG hypometabolism; the remaining 3 did not. Among the patients showing hypometabolism, 8 had a prerolandic pattern of which 7 had nonfluent speech including progressive nonfluent aphasia (n=3), PAS (n=1), and mixed nonfluent aphasia/ apraxia of speech (n=3); the other patient had PPA unclassifiable. The remaining 13 had a postrolandic pattern, all with fluent speech (P<.001), including logopenic progressive aphasia (n=6), progressive fluent aphasia (n=6), and semantic dementia (n=1). Patterns of hypometabolism differed between the nonfluent variants and between the fluent variants, including progressive fluent aphasia. Conclusion: Patterns of FDG-PET hypometabolism support the clinical categorizations of fluency, the distinction of apraxia ofspeechfromprogressivenonfluentaphasia,and the designation of a progressive fluent aphasia category.",
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AU - Duffy, Joseph R.

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AU - Claassen, Daniel O.

AU - Whitwell, Jennifer Lynn

AU - Peller, Patrick J.

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