Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue

Lothar Lilge, Thomas J Flotte, Irene E. Kochevar, James W. Foley, Brian C. Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

A new fiber optic detector to measure optical radiant energy fluence rates in tissue has been developed by incorporating a fluorescent dye into the rounded tip of a polymethylmethacrylate cylindrical extension on a quartz optical fiber. Model probes were built to test the concept. Nile Blue A free base was used as the fluorescent dye with the absorption maximum blue-shifted to 495 nm, giving an emission maximum at 580 nm. Fluorescence (>570 nm) was monitored using a photodiode. The response was linear with modest fluence rates in the 1 mW/cm2 to 700 mW/cm2 range. The angular response of the probe was investigated using a 3 mm diameter scaled-up model. The influence of dye concentration, geometrical shape and distance between fluorescence tip and fiber were evaluated. A 3 mm long rounded tip, separated by 7 mm from the distal end of the fiber, was isotropic in angular response to within ± 10% between 0° and 150° of the forward direction.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsThomas J. Dougherty
Place of PublicationBellingham, WA, United States
PublisherPubl by Int Soc for Optical Engineering
Pages106-117
Number of pages12
Volume1203
ISBN (Print)0819402443
StatePublished - 1990
Externally publishedYes
EventProceedings of Photodynamic Therapy: Mechanisms II - Los Angeles, CA, USA
Duration: Jan 16 1990Jan 17 1990

Other

OtherProceedings of Photodynamic Therapy: Mechanisms II
CityLos Angeles, CA, USA
Period1/16/901/17/90

Fingerprint

Light scattering
Dosimetry
dosimeters
Optical fibers
light scattering
Dyes
optical fibers
dyes
Tissue
probes
fluence
Fluorescence
fluorescence
fibers
Fibers
Photodiodes
Fiber optics
photodiodes
Quartz
fiber optics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lilge, L., Flotte, T. J., Kochevar, I. E., Foley, J. W., & Wilson, B. C. (1990). Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. In T. J. Dougherty (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1203, pp. 106-117). Bellingham, WA, United States: Publ by Int Soc for Optical Engineering.

Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. / Lilge, Lothar; Flotte, Thomas J; Kochevar, Irene E.; Foley, James W.; Wilson, Brian C.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Thomas J. Dougherty. Vol. 1203 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1990. p. 106-117.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lilge, L, Flotte, TJ, Kochevar, IE, Foley, JW & Wilson, BC 1990, Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. in TJ Dougherty (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1203, Publ by Int Soc for Optical Engineering, Bellingham, WA, United States, pp. 106-117, Proceedings of Photodynamic Therapy: Mechanisms II, Los Angeles, CA, USA, 1/16/90.
Lilge L, Flotte TJ, Kochevar IE, Foley JW, Wilson BC. Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. In Dougherty TJ, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1203. Bellingham, WA, United States: Publ by Int Soc for Optical Engineering. 1990. p. 106-117
Lilge, Lothar ; Flotte, Thomas J ; Kochevar, Irene E. ; Foley, James W. ; Wilson, Brian C. / Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. Proceedings of SPIE - The International Society for Optical Engineering. editor / Thomas J. Dougherty. Vol. 1203 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1990. pp. 106-117
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