Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue

Lothar Lilge, Thomas J Flotte, Irene E. Kochevar, James W. Foley, Brian C. Wilson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

A new fiber optic detector to measure optical radiant energy fluence rates in tissue has been developed by incorporating a fluorescent dye into the rounded tip of a polymethylmethacrylate cylindrical extension on a quartz optical fiber. Model probes were built to test the concept. Nile Blue A free base was used as the fluorescent dye with the absorption maximum blue-shifted to 495 nm, giving an emission maximum at 580 nm. Fluorescence (>570 nm) was monitored using a photodiode. The response was linear with modest fluence rates in the 1 mW/cm2 to 700 mW/cm2 range. The angular response of the probe was investigated using a 3 mm diameter scaled-up model. The influence of dye concentration, geometrical shape and distance between fluorescence tip and fiber were evaluated. A 3 mm long rounded tip, separated by 7 mm from the distal end of the fiber, was isotropic in angular response to within ± 10% between 0° and 150° of the forward direction.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsThomas J. Dougherty
Place of PublicationBellingham, WA, United States
PublisherPubl by Int Soc for Optical Engineering
Pages106-117
Number of pages12
Volume1203
ISBN (Print)0819402443
StatePublished - 1990
Externally publishedYes
EventProceedings of Photodynamic Therapy: Mechanisms II - Los Angeles, CA, USA
Duration: Jan 16 1990Jan 17 1990

Other

OtherProceedings of Photodynamic Therapy: Mechanisms II
CityLos Angeles, CA, USA
Period1/16/901/17/90

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

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  • Cite this

    Lilge, L., Flotte, T. J., Kochevar, I. E., Foley, J. W., & Wilson, B. C. (1990). Fluorescent-tip optical fiber probe for quantitative light dosimetry in light scattering media and in tissue. In T. J. Dougherty (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1203, pp. 106-117). Publ by Int Soc for Optical Engineering.