Abstract
Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progressive disease had ≥2 anomalies and a high percentage of neoplastic nuclei. Anomalies of genes for basic fibroblast growth factor, interleukin 4, vascular endothelial growth factor or TCL1 were not detected. Deletions in IGHv occurred in 25% of patients and correlated with IGHv gene expression. Probes for 6q23 detected more deletions in 6q than probes for 6q21.
Original language | English (US) |
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Pages (from-to) | 253-262 |
Number of pages | 10 |
Journal | Leukemia Research |
Volume | 29 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2005 |
Keywords
- Angiogenesis
- CLL
- FISH
- IGHv
- TCL1
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research