Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, βγ subunits, small GTPase CDC42, and partly by Rac-1

Medicine & Life Sciences

• Monomeric GTP-Binding Proteins 100%
• Protein Subunits 96%
• Pertussis Toxin 96%
• GTP-Binding Proteins 84%
• Vascular Endothelial Growth Factor A 73%
• Endothelial Cells 62%
• Down-Regulation 59%
• Cell Proliferation 55%
• Type C Phospholipases 23%
• Cell Movement 17%
• 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 14%
• 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 14%
• Vascular Endothelial Growth Factor Receptor-1 13%
• Vascular Endothelial Growth Factor Receptor-2 13%
• Wortmannin 13%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12%
• Receptor Protein-Tyrosine Kinases 11%
• Phosphatidylinositol 3-Kinase 10%
• Phosphatidylinositol 3-Kinases 10%
• ErbB Receptors 10%
• Endothelium 9%
• Phosphorylation 7%

Chemical Compounds

• Permeability 67%
• Antiproliferative 63%
• Toxin 40%
• LY294002 38%
• Phospholipase C Inhibitor 37%
• Wortmannin 36%
• BAPTA 35%
• Protein 35%
• Tyrosine 19%