Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.

Original languageEnglish (US)
Pages (from-to)99-115
Number of pages17
JournalCytometry Part B - Clinical Cytometry
Volume96
Issue number2
DOIs
StatePublished - Mar 2019

Keywords

  • NK-cell lymphoproliferative disorders
  • T-cell lymphoproliferative disorder
  • flow cytometry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Fingerprint Dive into the research topics of 'Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders'. Together they form a unique fingerprint.

Cite this