TY - JOUR
T1 - Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders
AU - Jevremovic, Dragan
AU - Olteanu, Horatiu
N1 - Publisher Copyright:
© 2019 International Clinical Cytometry Society
PY - 2019/3
Y1 - 2019/3
N2 - This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.
AB - This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.
KW - NK-cell lymphoproliferative disorders
KW - T-cell lymphoproliferative disorder
KW - flow cytometry
UR - http://www.scopus.com/inward/record.url?scp=85061108359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061108359&partnerID=8YFLogxK
U2 - 10.1002/cyto.b.21768
DO - 10.1002/cyto.b.21768
M3 - Review article
C2 - 30729667
AN - SCOPUS:85061108359
SN - 1552-4949
VL - 96
SP - 99
EP - 115
JO - Cytometry Part B - Clinical Cytometry
JF - Cytometry Part B - Clinical Cytometry
IS - 2
ER -