Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.

Original languageEnglish (US)
JournalCytometry Part B - Clinical Cytometry
DOIs
StatePublished - Jan 1 2019

Fingerprint

Lymphoproliferative Disorders
Natural Killer Cells
Flow Cytometry
T-Lymphocytes
Immunophenotyping
Therapeutics

Keywords

  • flow cytometry
  • NK-cell lymphoproliferative disorders
  • T-cell lymphoproliferative disorder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

@article{27bc66f63f3e446b9ab53c789ee45375,
title = "Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders",
abstract = "This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.",
keywords = "flow cytometry, NK-cell lymphoproliferative disorders, T-cell lymphoproliferative disorder",
author = "Dragan Jevremovic and Horatiu Olteanu",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/cyto.b.21768",
language = "English (US)",
journal = "Cytometry",
issn = "1552-4949",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Flow Cytometry Applications in the Diagnosis of T/NK-Cell Lymphoproliferative Disorders

AU - Jevremovic, Dragan

AU - Olteanu, Horatiu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.

AB - This article provides an overview of the role of flow cytometry in the diagnosis, prognosis, and follow-up of T and NK-cell lymphoproliferative disorders. For each category, we will briefly discuss the immunophenotypic features of normal T and NK cells, and address technical issues in flow cytometry, the approach to diagnosis in various contexts, pitfalls in interpretation, and its use in follow-up and post-therapy management. In addition to reviewing the diagnostic, prognostic, and therapeutic utility of flow cytometric immunophenotyping in several of specific T and NK cell entities, we will also cover some of the new immunophenotypic markers. Furthermore, we will touch upon incorporation of flow cytometry in the final diagnosis, including correlation with other ancillary tests.

KW - flow cytometry

KW - NK-cell lymphoproliferative disorders

KW - T-cell lymphoproliferative disorder

UR - http://www.scopus.com/inward/record.url?scp=85061108359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061108359&partnerID=8YFLogxK

U2 - 10.1002/cyto.b.21768

DO - 10.1002/cyto.b.21768

M3 - Review article

C2 - 30729667

AN - SCOPUS:85061108359

JO - Cytometry

JF - Cytometry

SN - 1552-4949

ER -