Flavones and sesquiterpene lactones from Achillea atrata subsp, multifida: Antimicrobial activity

Ivana Aljančić, Vlatka Vajs, Nebojša Menković, Ivanka Karadžić, Nenad Juranić, Slobodan Milosavljević, Slobodan Macura

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp, multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.

Original languageEnglish (US)
Pages (from-to)909-911
Number of pages3
JournalJournal of Natural Products
Volume62
Issue number6
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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