Flat adenomas in a colon cancer-prone kindred

Henry T. Lynch; Tom Smyrk; Stephen J. Lanspa; Joseph N. Marcus; Mary Kriegler; Jane F. Lynch; Henry D. Appelman

doi:10.1093/jnci/80.4.278

Flat adenomas in a colon cancer-prone kindred

Henry T. Lynch, Tom Smyrk, Stephen J. Lanspa, Joseph N. Marcus, Mary Kriegler, Jane F. Lynch, Henry D. Appelman

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

Original language	English (US)
Pages (from-to)	278-282
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	80
Issue number	4
DOIs	https://doi.org/10.1093/jnci/80.4.278
State	Published - Apr 20 1988

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Flat adenomas in a colon cancer-prone kindred",

abstract = "We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term {"}flat adenoma{"} for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].",

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note = "Funding Information: Supported by Public Health Service grant CA-42705 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services.",

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AU - Lynch, Jane F.

AU - Appelman, Henry D.

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N2 - We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

AB - We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term "flat adenoma" for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278-282].

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Flat adenomas in a colon cancer-prone kindred

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