TY - JOUR
T1 - FKBP51 regulation of AKT/protein kinase B phosphorylation
AU - Wang, Liewei
N1 - Funding Information:
K22 CA130828 , R01 CA138461 , U19 GM61388 ( The Pharmacogenetics Research Network ), ASPET-Astellas Award and a PhRMA Foundation ‘Center of Excellence in Clinical Pharmacology’ Award.
PY - 2011/8
Y1 - 2011/8
N2 - FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). FKBP family members are targets for drugs such as rapamycin. Although FKBP51 shares characteristics with other FKBPs, it also has unique features, especially the role in its regulation of important signaling pathways such as the AKT kinase/protein kinase B pathway. In this review, we will focus on the function of FKBP51 as a scaffolding protein in the regulation of AKT activation and, in turn, its role in tumorigenesis and response to chemotherapy.
AB - FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). FKBP family members are targets for drugs such as rapamycin. Although FKBP51 shares characteristics with other FKBPs, it also has unique features, especially the role in its regulation of important signaling pathways such as the AKT kinase/protein kinase B pathway. In this review, we will focus on the function of FKBP51 as a scaffolding protein in the regulation of AKT activation and, in turn, its role in tumorigenesis and response to chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=80051670473&partnerID=8YFLogxK
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U2 - 10.1016/j.coph.2011.03.008
DO - 10.1016/j.coph.2011.03.008
M3 - Review article
C2 - 21498116
AN - SCOPUS:80051670473
SN - 1471-4892
VL - 11
SP - 360
EP - 364
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 4
ER -