Five-Year Mortality After Transient Ischemic Attack: Focus on Cardiometabolic Comorbidity and Hospital Readmission

Mohammed Yousufuddin, Nathan Young, Lawrence Keenan, Tammy Olson, Jessica Shultz, Taylor Doyle, Eimad M. Ahmmad, Kogulavadanan Arumaithurai, Paul Y Takahashi, Mohammad H Murad

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: We aimed at providing estimates of mortality associated with cardiometabolic comorbidity and incident readmission from cardiometabolic as compared with noncardiometabolic conditions after a first transient ischemic attack.

METHODS: Between 2000 and 2015, patients hospitalized for a first transient ischemic attack were examined for cardiometabolic comorbidities (diabetes mellitus, coronary artery disease, heart failure, and atrial fibrillation), 5-year incident hospitalization, and time to death.

RESULTS: Of 251 patients with transient ischemic attack, 134 (53%) had at least 1 and 55 (22%) had at least 2 cardiometabolic conditions. By 5 years, 491 readmissions (134 [27%] cardiometabolic and 357 [73%] noncardiometabolic) and 75 deaths (27 [36%] cardiometabolic and 47 [64%] noncardiometabolic) were observed. Mortality was increased with any concurrent cardiometabolic comorbidity (hazard ratio, 1.89; 95% confidence interval, 1.17-3.03; P=0.0089) with multiplicative mortality risk from a combination of coronary artery disease and heart failure. Each hospitalization was associated with a 1.5-fold risk of death (95% confidence interval, 1.37-1.64; P<0.0001). Risk of cardiometabolic and noncardiometabolic mortality was correlated with the corresponding category-specific readmission.

CONCLUSIONS: Among patients hospitalized for first transient ischemic attack, 5-year mortality is associated with concurrent cardiometabolic comorbidity and rates of subsequent hospitalization.

Original languageEnglish (US)
Pages (from-to)730-733
Number of pages4
JournalStroke
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Patient Readmission
Transient Ischemic Attack
Comorbidity
Mortality
Hospitalization
Coronary Artery Disease
Heart Failure
Confidence Intervals
Atrial Fibrillation
Diabetes Mellitus

Keywords

  • confidence interval
  • heart failure
  • humans
  • ischemic attack, transient
  • mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Five-Year Mortality After Transient Ischemic Attack : Focus on Cardiometabolic Comorbidity and Hospital Readmission. / Yousufuddin, Mohammed; Young, Nathan; Keenan, Lawrence; Olson, Tammy; Shultz, Jessica; Doyle, Taylor; Ahmmad, Eimad M.; Arumaithurai, Kogulavadanan; Takahashi, Paul Y; Murad, Mohammad H.

In: Stroke, Vol. 49, No. 3, 01.03.2018, p. 730-733.

Research output: Contribution to journalArticle

Yousufuddin, M, Young, N, Keenan, L, Olson, T, Shultz, J, Doyle, T, Ahmmad, EM, Arumaithurai, K, Takahashi, PY & Murad, MH 2018, 'Five-Year Mortality After Transient Ischemic Attack: Focus on Cardiometabolic Comorbidity and Hospital Readmission', Stroke, vol. 49, no. 3, pp. 730-733. https://doi.org/10.1161/STROKEAHA.117.020022
Yousufuddin, Mohammed ; Young, Nathan ; Keenan, Lawrence ; Olson, Tammy ; Shultz, Jessica ; Doyle, Taylor ; Ahmmad, Eimad M. ; Arumaithurai, Kogulavadanan ; Takahashi, Paul Y ; Murad, Mohammad H. / Five-Year Mortality After Transient Ischemic Attack : Focus on Cardiometabolic Comorbidity and Hospital Readmission. In: Stroke. 2018 ; Vol. 49, No. 3. pp. 730-733.
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