FIV: From lentivirus to lentivector

Dyana T. Saenz, Eric M. Poeschla

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Molecular virological understanding of the feline immunodeficiency virus (FIV) life cycle is increasing, facilitating rational derivation of improved vectors from this non-primate lentivirus. The packaging signal has been mapped, a central DNA flap has been identified, and class I integrase mutants have been validated. Vector systems with improved effectiveness and safety profiles are being applied by a number of laboratories in several pre-clinical models, with demonstrated efficacy in human tissues. The comparative lentivirological research that facilitates FIV vector development may also yield insights into the still enigmatic molecular basis for a signature lentiviral property with pathogenetic and therapeutic importance: permanent transgene integration in non-dividing cells. This review discusses virological aspects of lentiviral vector development, as well as some recent controversies and applications.

Original languageEnglish (US)
Pages (from-to)S95-S104
JournalJournal of Gene Medicine
Volume6
Issue numberSUPPL. 1
DOIs
StatePublished - Feb 1 2004

Keywords

  • FIV
  • HIV
  • Lentiviral vectors

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery
  • Genetics(clinical)

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  • Cite this

    Saenz, D. T., & Poeschla, E. M. (2004). FIV: From lentivirus to lentivector. Journal of Gene Medicine, 6(SUPPL. 1), S95-S104. https://doi.org/10.1002/jgm.500