Heme oxygenase (HO)-1 degrades heme and protects against oxidative stress, but it has not been pharmacologically induced in humans. In this randomized study of 10 healthy volunteers, hemin (3mg/kg intravenously in 25% albumin) was shown to increase plasma HO-1 protein concentration four-to fivefold and HO-1 activity ∼15-fold relative to baseline at 24 and 48h (placebo 56.41±6.31 (baseline), 69.79±13.00 (24h), 77.44±10.62 (48h) vs. hemin 71.70±9.20 (baseline), 1,126.20 293.30 (24h), 1,192.20 333.30 (48h)) in four of five subjects as compared with albumin alone (P≤0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans.
ASJC Scopus subject areas
- Pharmacology (medical)