FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia

Ayalew Tefferi, Terra L. Lasho, Stephanie R. Brockman, Michelle A. Elliott, Angela Dispenzieri, Animesh Pardanani

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Laboratory methods to detect both FIP1L1-PDGFRA and c-kit D816V mutations were combined with immunomagnetic cell separation to study the extent of clonal involvement by both myeloid and lymphoid cells in 3 patients with systemic mastocytosis associated with eosinophilia. The results suggested an early stem cell origin for the FIP1L1-PDGFRA mutation.

Original languageEnglish (US)
Pages (from-to)871-873
Number of pages3
JournalHaematologica
Volume89
Issue number7
StatePublished - Jul 1 2004

Keywords

  • Eosinophilia
  • Mastocytosis
  • Mutations
  • Systemic mast cell disease

ASJC Scopus subject areas

  • Hematology

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