Quantitation of the relationship between regional myocardial passive length and tension during diastole and the contractile capability of the myocardium during the ensuing systole is the overall objective of these studies. To achieve this objective it should first be possible to adequately estimate the regional material properties of the passive myocardium in the intact, working left ventricle in the intact thorax. With this objective in mind the question as to whether the passive material properties of the myocardium can be reproducibly estimated independent of ventricular shape and dimensions and transmural pressure must be answered. In this experimental series increase in transmural pressure was induced either by restricting ejection during systole by acutely inflating a balloon in the ascending aorta or by acute, transient reduction of blood flow through a distal branch of the left circumflex coronary artery, or both. The specific objective in this study was to compare the role of transient extracardiac and transient myocardial causes for elevated transmural pressure on global myocardial material properties.
|Original language||English (US)|
|Number of pages||15|
|Journal||European Journal of Cardiology|
|State||Published - Dec 1 1978|
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