@article{aa5a5b2f7c24456881f57a42e261d1d2,
title = "Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci",
abstract = "Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown.We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies.",
author = "Niha Zubair and Mariaelisa Graff and Ambite, {Jose Luis} and Bush, {William S.} and Gleb Kichaev and Yingchang Lu and Ani Manichaikul and Sheu, {Wayne H.H.} and Devin Absher and Assimes, {Themistocles L.} and Bielinski, {Suzette J.} and Bottinger, {Erwin P.} and Petra Buzkova and Chuang, {Lee Ming} and Chung, {Ren Hua} and Barbara Cochran and Logan Dumitrescu and Omri Gottesman and Haessler, {Jeffrey W.} and Christopher Haiman and Gerardo Heiss and Hsiung, {Chao A.} and Hung, {Yi Jen} and Hwu, {Chii Min} and Juang, {Jyh Ming J.} and Marchand, {Loic Le} and Lee, {I. Te} and Lee, {Wen Jane} and Lin, {Li An} and Danyu Lin and Lin, {Shih Yi} and Mackey, {Rachel H.} and Martin, {Lisa W.} and Bogdan Pasaniuc and Ulrike Peters and Irene Predazzi and Thomas Quertermous and Reiner, {Alex P.} and Jennifer Robinson and Rotter, {Jerome I.} and Ryckman, {Kelli K.} and Schreiner, {Pamela J.} and Eli Stahl and Ran Tao and Tsai, {Michael Y.} and Waite, {Lindsay L.} and Wang, {Tzung Dau} and Steven Buyske and Chen, {Yii Der Ida} and Iona Cheng and Crawford, {Dana C.} and Loos, {Ruth J.F.} and Rich, {Stephen S.} and Myriam Fornage and North, {Kari E.} and Charles Kooperberg and Carty, {Cara L.}",
note = "Funding Information: The PAGE consortium thanks the staff and participants of all PAGE studies for their important contributions. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The complete list of PAGE members can be found at http://www.pagestudy. org. Assistance with phenotype harmonization, SNP selection and annotation, data cleaning, data management, integration and dissemination, and general study coordination was provided by the PAGE Coordinating Center (U01HG004801-01 and its NHGRI ARRA supplement). The National Institutes of Mental Health also contributes to the support for the Coordinating Center. See Detailed Acknowledgment in Supplementary Information for PAGE study-specific acknowledgements. The PAGE program is funded by the National Human Genome Research Institute (NHGRI), supported by U01HG004803 (CALiCo), U01HG004798 (EAGLE), U01HG004802 (MEC), U01HG004790 (WHI), and U01HG004801 (Coordinating Center), and their respective NHGRI ARRA supplements. Publisher Copyright: {\textcopyright} The Author 2016.",
year = "2016",
month = dec,
day = "15",
doi = "10.1093/hmg/ddw358",
language = "English (US)",
volume = "25",
pages = "5500--5512",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "24",
}