Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb

Bo Johanneson, Shannon K. McDonnell, Danielle M. Karyadi, Scott J. Hebbring, Liang Wang, Kerry Deutsch, Laura McIntosh, Erika M. Kwon, Miia Suuriniemi, Janet L. Stanford, Daniel J Schaid, Elaine A. Ostrander, Stephen N Thibodeau

Research output: Contribution to journalArticle

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Abstract

Genetic studies suggest that hereditary prostate cancer is a genetically heterogeneous disease with multiple contributing loci. Studies of high-risk prostate cancer families selected for aggressive disease, analysis of large multigenerational families, and a meta-analysis from the International Consortium for Prostate Cancer Genetics (ICPCG), all highlight chromosome 22q12.3 as a susceptibility locus with strong statistical significance. Recently, two publications have narrowed the 22q12.3 locus to a 2.18 Mb interval using 54 high-risk families from the ICPCG collaboration, as defined by three recombination events on either side of the locus. In this paper, we present the results from fine mapping studies at 22q12.3 using both haplotype and recombination data from 42 high-risk families contributed from the Mayo Clinic and the Prostate Cancer Genetic Research Study (PROGRESS) mapping studies. No clear consensus interval is present when all families are used. However, in the subset of 14 families with ≥5 affected men per family, a 2.53-Mb shared consensus segment that overlaps with the previously published interval is identified. Combining these results with data from the earlier ICPCG study reduces the three-recombination interval at 22q12.3 to approximately 1.36 Mb.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalHuman Genetics
Volume123
Issue number1
DOIs
StatePublished - Feb 2008

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Chromosomes
Prostatic Neoplasms
Genetic Recombination
Consensus
Genetic Research
Familial Prostate cancer
Haplotypes
Publications
Meta-Analysis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. / Johanneson, Bo; McDonnell, Shannon K.; Karyadi, Danielle M.; Hebbring, Scott J.; Wang, Liang; Deutsch, Kerry; McIntosh, Laura; Kwon, Erika M.; Suuriniemi, Miia; Stanford, Janet L.; Schaid, Daniel J; Ostrander, Elaine A.; Thibodeau, Stephen N.

In: Human Genetics, Vol. 123, No. 1, 02.2008, p. 65-75.

Research output: Contribution to journalArticle

Johanneson, B, McDonnell, SK, Karyadi, DM, Hebbring, SJ, Wang, L, Deutsch, K, McIntosh, L, Kwon, EM, Suuriniemi, M, Stanford, JL, Schaid, DJ, Ostrander, EA & Thibodeau, SN 2008, 'Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb', Human Genetics, vol. 123, no. 1, pp. 65-75. https://doi.org/10.1007/s00439-007-0451-y
Johanneson, Bo ; McDonnell, Shannon K. ; Karyadi, Danielle M. ; Hebbring, Scott J. ; Wang, Liang ; Deutsch, Kerry ; McIntosh, Laura ; Kwon, Erika M. ; Suuriniemi, Miia ; Stanford, Janet L. ; Schaid, Daniel J ; Ostrander, Elaine A. ; Thibodeau, Stephen N. / Fine mapping of familial prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. In: Human Genetics. 2008 ; Vol. 123, No. 1. pp. 65-75.
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