Findings in neonates delivered of renal transplant patients

C. Pabelick, F. Kemmer, B. Koletzko

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Renal transplant patients who become pregnant require continued immunosuppression. Little is known on the risks of infants born under these conditions. We observed 6 neonates of renal transplant patients, of whom 4 were premature and 3 small for gestational age (SGA). There were no congenital malformations. Transient thrombopenia in 1 preterm baby probably resulted from maternal immunosuppression. Further 232 cases were published since 1980. Among the total of 238 patients, including our observations, rates for prematurity (49%) and SGA-infants (29%) were high, 6% had congenital malformations. Maternal immunosuppression with Cyclosporin A, as compared to Azathioprin, seems to carry a higher risk of prematurity (66 vs. 43%) and SGA babies (56 vs. 19%). On the contrary, Azathioprin might be more muta- and teratogenic. At present, no data are available on the longterm outcome of these children.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalMonatsschrift fur Kinderheilkunde
Volume139
Issue number3
StatePublished - Jan 1 1991

Keywords

  • azathioprin
  • cyclosporin A
  • immunosuppression
  • prednisolon

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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