Renal transplant patients who become pregnant require continued immunosuppression. Little is known on the risks of infants born under these conditions. We observed 6 neonates of renal transplant patients, of whom 4 were premature and 3 small for gestational age (SGA). There were no congenital malformations. Transient thrombopenia in 1 preterm baby probably resulted from maternal immunosuppression. Further 232 cases were published since 1980. Among the total of 238 patients, including our observations, rates for prematurity (49%) and SGA-infants (29%) were high, 6% had congenital malformations. Maternal immunosuppression with Cyclosporin A, as compared to Azathioprin, seems to carry a higher risk of prematurity (66 vs. 43%) and SGA babies (56 vs. 19%). On the contrary, Azathioprin might be more muta- and teratogenic. At present, no data are available on the longterm outcome of these children.
|Original language||English (US)|
|Number of pages||5|
|Journal||Monatsschrift fur Kinderheilkunde|
|State||Published - 1991|
- cyclosporin A
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health