Abstract
Randomized clinical trials (RCTs) are relied upon for determining the standard of care and changes to the standard of care in oncology. Through data sharing, the pooled individual patient data (IPD) from these trials can provide high-quality sources and enriched power for analyses beyond the original goals of each trial. To address important scientific questions in early-stage colon cancer, the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group has continuously integrated IPD from large adjuvant colon cancer RCTs conducted worldwide. Through June 2016, IPD from over 40,000 patients from 27 major trials (1977 to 2009) have been assembled. Over the past 20 years, a variety of clinical questions have been investigated and addressed by ACCENT collaborations. Many of the findings have provided additional understanding of treatment mechanisms, suggested changes or reinforced quality patient care, and informed and improved the design for the current and next generation of RCTs. We review these significant contributions from the ACCENT collaboration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 251-259 |
| Number of pages | 9 |
| Journal | Current Colorectal Cancer Reports |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 2016 |
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Keywords
- ACCENT
- Adjuvant treatment
- Colon cancer
- Data sharing
- Disease-free survival
- Individual patient data
- Meta-database
- Overall survival
- Pooled analysis
- Surrogate endpoint
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Hepatology
Cite this
Findings from the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group : the Power of Pooled Individual Patient Data from Multiple Clinical Trials. / Shi, Qian D; Sargent, Daniel J.; Renfro, Lindsay A.
In: Current Colorectal Cancer Reports, Vol. 12, No. 5, 01.10.2016, p. 251-259.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Findings from the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group
T2 - the Power of Pooled Individual Patient Data from Multiple Clinical Trials
AU - Shi, Qian D
AU - Sargent, Daniel J.
AU - Renfro, Lindsay A.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Randomized clinical trials (RCTs) are relied upon for determining the standard of care and changes to the standard of care in oncology. Through data sharing, the pooled individual patient data (IPD) from these trials can provide high-quality sources and enriched power for analyses beyond the original goals of each trial. To address important scientific questions in early-stage colon cancer, the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group has continuously integrated IPD from large adjuvant colon cancer RCTs conducted worldwide. Through June 2016, IPD from over 40,000 patients from 27 major trials (1977 to 2009) have been assembled. Over the past 20 years, a variety of clinical questions have been investigated and addressed by ACCENT collaborations. Many of the findings have provided additional understanding of treatment mechanisms, suggested changes or reinforced quality patient care, and informed and improved the design for the current and next generation of RCTs. We review these significant contributions from the ACCENT collaboration.
AB - Randomized clinical trials (RCTs) are relied upon for determining the standard of care and changes to the standard of care in oncology. Through data sharing, the pooled individual patient data (IPD) from these trials can provide high-quality sources and enriched power for analyses beyond the original goals of each trial. To address important scientific questions in early-stage colon cancer, the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group has continuously integrated IPD from large adjuvant colon cancer RCTs conducted worldwide. Through June 2016, IPD from over 40,000 patients from 27 major trials (1977 to 2009) have been assembled. Over the past 20 years, a variety of clinical questions have been investigated and addressed by ACCENT collaborations. Many of the findings have provided additional understanding of treatment mechanisms, suggested changes or reinforced quality patient care, and informed and improved the design for the current and next generation of RCTs. We review these significant contributions from the ACCENT collaboration.
KW - ACCENT
KW - Adjuvant treatment
KW - Colon cancer
KW - Data sharing
KW - Disease-free survival
KW - Individual patient data
KW - Meta-database
KW - Overall survival
KW - Pooled analysis
KW - Surrogate endpoint
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UR - http://www.scopus.com/inward/citedby.url?scp=84980028062&partnerID=8YFLogxK
U2 - 10.1007/s11888-016-0331-8
DO - 10.1007/s11888-016-0331-8
M3 - Review article
VL - 12
SP - 251
EP - 259
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
SN - 1556-3790
IS - 5
ER -