Finding balance: T cell regulatory receptor expression during aging

Mary M. Cavanagh, Qian Qi, Cornelia M. Weyand, Jörg J. Goronzy

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to altered immunity during aging.

Original languageEnglish (US)
Pages (from-to)398-413
Number of pages16
JournalAging and Disease
Volume2
Issue number5
StatePublished - 2011

Keywords

  • Aging
  • Inhibitory receptors
  • NK receptors
  • T cell costimulation
  • T cell regulation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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