Abstract
Aging is associated with a variety of changes to immune responsiveness. Reduced protection against infection, reduced responses to vaccination and increased risk of autoimmunity are all hallmarks of advanced age. Here we consider how changes in the expression of regulatory receptors on the T cell surface contribute to altered immunity during aging.
Original language | English (US) |
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Pages (from-to) | 398-413 |
Number of pages | 16 |
Journal | Aging and Disease |
Volume | 2 |
Issue number | 5 |
State | Published - 2011 |
Keywords
- Aging
- Inhibitory receptors
- NK receptors
- T cell costimulation
- T cell regulation
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Geriatrics and Gerontology
- Clinical Neurology
- Cell Biology