Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation

Wen Lang Lin, Jada Lewis, Shu Hui Yen, Michael Hutton, Dennis W. Dickson

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Abstract

We recently reported a transgenic mouse line (JNPL3) that expresses mutant (P301L) tau and develops neurofibrillary tangles composed of filamentous tau aggregates. Here we show that these mice have abnormal tau filaments not only in neurons, but also in oligodendrocytes and astrocytes. Similar results were detected in another transgenic line (JNPL2+3+) that expresses the longest human tau isoform with the P301L mutation. The ultrastructure of the tau filaments and immunoreactivity with tau and ubiquitin antibodies were similar in glia and neurons. Given similarities of the lesions in the mice to human neuronal and glial inclusions, these transgenic mice appear to be a valuable model to study pathogenesis of the neurodegenerative tauopathies.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalAmerican Journal of Pathology
Volume162
Issue number1
DOIs
StatePublished - Jan 1 2003

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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