Fibrous dysplasia of bone associated with primary hyperparathyroidism

Adina F. Turcu, Bart Clarke

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Fibrous dysplasia of bone and primary hyperparathyroidism (PHPT) may occur in patients with McCune-Albright Syndrome. A small number of cases with both diagnoses that are not associated with the above-mentioned genetic disorder have been published in the literature. It is uncertain if these disorders are linked in some way. In the present study, we aimed to further explore a potential relationship between PHPT and fibrous dysplasia of bone.Methods: We conducted a retrospective review of all cases seen at Mayo Clinic, Rochester, Minnesota, between 1976 and 2011 that were diagnosed with both PHPT and fibrous dysplasia of bone.Results: We identified 10 patients who were diagnosed with both PHPT and fibrous dysplasia of bone. Fibrous dysplasia was polyostotic in 7 (70%) cases. It affected the lower extremities in 6 (60%) patients, the skull or facial bones in 4 (40%), and was localized to one rib in 1 patient (10%). In 4 patients, fibrous dysplasia was diagnosed first, between 9 to 50 years before being diagnosed with PHPT. Two cases of fibrous dysplasia were recognized between 2 and 5 years after the diagnosis of PHPT. The remaining 4 patients were diagnosed with both conditions at approximately the same time.Conclusion: It remains unclear if the association between fibrous dysplasia of bone and PHPT is more than coincidental, although the possibility of a rare familial genetic syndrome is not completely excluded.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalEndocrine Practice
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Fibrous Dysplasia of Bone
Primary Hyperparathyroidism
Polyostotic Fibrous Dysplasia
Facial Bones
Inborn Genetic Diseases
Ribs
Skull
Lower Extremity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Fibrous dysplasia of bone associated with primary hyperparathyroidism. / Turcu, Adina F.; Clarke, Bart.

In: Endocrine Practice, Vol. 19, No. 2, 01.03.2013, p. 226-230.

Research output: Contribution to journalArticle

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