Fibrolamellar carcinoma: Diagnosis and diagnostic pitfalls

Research output: Contribution to journalReview article

Abstract

Fibrolamellar carcinomas are a unique primary liver cancer that most commonly occur in teenaged individuals and young adults. They are not associated with chronic liver disease, and their etiology remains a mystery. The most important prognostic feature is tumor resectability. Overall, fibrolamellar carcinomas have a similar prognosis to that of typical hepatocellular carcinomas, after controlling for age and background liver disease. A diagnosis can be made only by histological findings. Distinctive histological features include large eosinophilic tumor cells, prominent tumor nucleoli, and extensive intratumoral fibrosis. The hematoxylin-eosin impression of fibrolamellar carcinoma can be confirmed with CK7 and CD68 immunostains. There are numerous diagnostic pitfalls, which are further discussed in this review. There is no effective chemotherapy to date, but molecular studies have identified several potential targets including epidermal growth factor receptor, mammalian target of rapamycin, and fibroblast growth factor receptor 1 pathways.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalPathology Case Reviews
Volume19
Issue number6
DOIs
StatePublished - Dec 11 2014

Fingerprint

Carcinoma
Liver Diseases
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
Sirolimus
Hematoxylin
Eosine Yellowish-(YS)
Liver Neoplasms
Epidermal Growth Factor Receptor
Young Adult
Hepatocellular Carcinoma
Fibrosis
Chronic Disease
Drug Therapy

Keywords

  • Fibrolamellar carcinoma
  • Hepatocellular carcinoma
  • Liver disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Fibrolamellar carcinoma : Diagnosis and diagnostic pitfalls. / Graham, Rondell; Torbenson, Michael.

In: Pathology Case Reviews, Vol. 19, No. 6, 11.12.2014, p. 309-315.

Research output: Contribution to journalReview article

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AB - Fibrolamellar carcinomas are a unique primary liver cancer that most commonly occur in teenaged individuals and young adults. They are not associated with chronic liver disease, and their etiology remains a mystery. The most important prognostic feature is tumor resectability. Overall, fibrolamellar carcinomas have a similar prognosis to that of typical hepatocellular carcinomas, after controlling for age and background liver disease. A diagnosis can be made only by histological findings. Distinctive histological features include large eosinophilic tumor cells, prominent tumor nucleoli, and extensive intratumoral fibrosis. The hematoxylin-eosin impression of fibrolamellar carcinoma can be confirmed with CK7 and CD68 immunostains. There are numerous diagnostic pitfalls, which are further discussed in this review. There is no effective chemotherapy to date, but molecular studies have identified several potential targets including epidermal growth factor receptor, mammalian target of rapamycin, and fibroblast growth factor receptor 1 pathways.

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