Abstract
Fibrolamellar carcinomas are a unique primary liver cancer that most commonly occur in teenaged individuals and young adults. They are not associated with chronic liver disease, and their etiology remains a mystery. The most important prognostic feature is tumor resectability. Overall, fibrolamellar carcinomas have a similar prognosis to that of typical hepatocellular carcinomas, after controlling for age and background liver disease. A diagnosis can be made only by histological findings. Distinctive histological features include large eosinophilic tumor cells, prominent tumor nucleoli, and extensive intratumoral fibrosis. The hematoxylin-eosin impression of fibrolamellar carcinoma can be confirmed with CK7 and CD68 immunostains. There are numerous diagnostic pitfalls, which are further discussed in this review. There is no effective chemotherapy to date, but molecular studies have identified several potential targets including epidermal growth factor receptor, mammalian target of rapamycin, and fibroblast growth factor receptor 1 pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 309-315 |
| Number of pages | 7 |
| Journal | Pathology Case Reviews |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 11 2014 |
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Keywords
- Fibrolamellar carcinoma
- Hepatocellular carcinoma
- Liver disease
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Fibrolamellar carcinoma : Diagnosis and diagnostic pitfalls. / Graham, Rondell; Torbenson, Michael.
In: Pathology Case Reviews, Vol. 19, No. 6, 11.12.2014, p. 309-315.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Fibrolamellar carcinoma
T2 - Diagnosis and diagnostic pitfalls
AU - Graham, Rondell
AU - Torbenson, Michael
PY - 2014/12/11
Y1 - 2014/12/11
N2 - Fibrolamellar carcinomas are a unique primary liver cancer that most commonly occur in teenaged individuals and young adults. They are not associated with chronic liver disease, and their etiology remains a mystery. The most important prognostic feature is tumor resectability. Overall, fibrolamellar carcinomas have a similar prognosis to that of typical hepatocellular carcinomas, after controlling for age and background liver disease. A diagnosis can be made only by histological findings. Distinctive histological features include large eosinophilic tumor cells, prominent tumor nucleoli, and extensive intratumoral fibrosis. The hematoxylin-eosin impression of fibrolamellar carcinoma can be confirmed with CK7 and CD68 immunostains. There are numerous diagnostic pitfalls, which are further discussed in this review. There is no effective chemotherapy to date, but molecular studies have identified several potential targets including epidermal growth factor receptor, mammalian target of rapamycin, and fibroblast growth factor receptor 1 pathways.
AB - Fibrolamellar carcinomas are a unique primary liver cancer that most commonly occur in teenaged individuals and young adults. They are not associated with chronic liver disease, and their etiology remains a mystery. The most important prognostic feature is tumor resectability. Overall, fibrolamellar carcinomas have a similar prognosis to that of typical hepatocellular carcinomas, after controlling for age and background liver disease. A diagnosis can be made only by histological findings. Distinctive histological features include large eosinophilic tumor cells, prominent tumor nucleoli, and extensive intratumoral fibrosis. The hematoxylin-eosin impression of fibrolamellar carcinoma can be confirmed with CK7 and CD68 immunostains. There are numerous diagnostic pitfalls, which are further discussed in this review. There is no effective chemotherapy to date, but molecular studies have identified several potential targets including epidermal growth factor receptor, mammalian target of rapamycin, and fibroblast growth factor receptor 1 pathways.
KW - Fibrolamellar carcinoma
KW - Hepatocellular carcinoma
KW - Liver disease
UR - http://www.scopus.com/inward/record.url?scp=84916631064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916631064&partnerID=8YFLogxK
U2 - 10.1097/PCR.0000000000000063
DO - 10.1097/PCR.0000000000000063
M3 - Review article
AN - SCOPUS:84916631064
VL - 19
SP - 309
EP - 315
JO - Pathology Case Reviews
JF - Pathology Case Reviews
SN - 1082-9784
IS - 6
ER -