Fibroblasts and the ground they walk on

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.

Original languageEnglish (US)
Pages (from-to)380-390
Number of pages11
JournalPhysiology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

Fingerprint

Fibroblasts
Wound Healing
Extracellular Matrix
Fibrosis

ASJC Scopus subject areas

  • Physiology

Cite this

Fibroblasts and the ground they walk on. / Tschumperlin, Daniel J.

In: Physiology, Vol. 28, No. 6, 01.11.2013, p. 380-390.

Research output: Contribution to journalArticle

@article{28c0588b05b94b0b9c813cce658ca93b,
title = "Fibroblasts and the ground they walk on",
abstract = "Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.",
author = "Tschumperlin, {Daniel J}",
year = "2013",
month = "11",
day = "1",
doi = "10.1152/physiol.00024.2013",
language = "English (US)",
volume = "28",
pages = "380--390",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Fibroblasts and the ground they walk on

AU - Tschumperlin, Daniel J

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.

AB - Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.

UR - http://www.scopus.com/inward/record.url?scp=84887035390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887035390&partnerID=8YFLogxK

U2 - 10.1152/physiol.00024.2013

DO - 10.1152/physiol.00024.2013

M3 - Article

VL - 28

SP - 380

EP - 390

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 6

ER -