Fibroblasts and the ground they walk on

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.

Original languageEnglish (US)
Pages (from-to)380-390
Number of pages11
JournalPhysiology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 2013

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ASJC Scopus subject areas

  • Physiology

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