TY - JOUR
T1 - Fibroblasts and the ground they walk on
AU - Tschumperlin, Daniel J.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.
AB - Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.
UR - http://www.scopus.com/inward/record.url?scp=84887035390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887035390&partnerID=8YFLogxK
U2 - 10.1152/physiol.00024.2013
DO - 10.1152/physiol.00024.2013
M3 - Review article
C2 - 24186933
AN - SCOPUS:84887035390
SN - 1548-9213
VL - 28
SP - 380
EP - 390
JO - Physiology
JF - Physiology
IS - 6
ER -