Fibroblastic foci in usual interstitial pneumonia: Idiopathic versus collagen vascular disease

Kevin R. Flaherty, Thomas V. Colby, William D. Travis, Galen B. Toews, Jeanette Mumford, Susan Murray, Victor J. Thannickal, Ella A. Kazerooni, Barry H. Gross, Joseph P. Lynch, Fernando J. Martinez

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

A histologic feature of usual interstitial pneumonia is the presence of fibroblastic foci. As some patients with usual interstitial pneumonia and an underlying collagen vascular disease have a better prognosis, we hypothesized that they would have fewer fibroblastic foci. Pathologists reviewed surgical lung biopsies from 108 patients with usual interstitial pneumonia (nine with collagen vascular disease) and assigned a score (absent 0, mild 1, moderate 2, and marked 3) for fibroblastic foci. Patients with idiopathic usual interstitial pneumonia had a higher median profusion of fibroblastic foci (1.75 vs. 1.0, p = 0.003). Baseline characteristics were similar, although patients with a collagen vascular disease were younger, had a shorter duration of symptoms, and had a higher percentage of predicted total lung capacity. Profusion of fibroblastic foci was the most discriminative feature for separating idiopathic from collagen vascular disease-associated usual interstitial pneumonia (odds ratio 8.31; 95% confidence interval, 1.98, 59.42; p = 0.002 for a one-unit increase in fibroblastic foci score). No deaths were noted in the collagen vascular disease-associated usual interstitial pneumonia group; 52 deaths occurred in the idiopathic usual interstitial pneumonia group (log rank; p = 0.005). We conclude that patients with collagen vascular disease-associated usual interstitial pneumonia have fewer fibroblastic foci and improved survival.

Original languageEnglish (US)
Pages (from-to)1410-1415
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume167
Issue number10
DOIs
StatePublished - May 15 2003
Externally publishedYes

Fingerprint

Collagen Diseases
Idiopathic Pulmonary Fibrosis
Vascular Diseases
Idiopathic Interstitial Pneumonias
Total Lung Capacity
Odds Ratio
Confidence Intervals
Biopsy
Lung
Survival

Keywords

  • Fibrolastic focus
  • Idiopathic pulmonary fibrosis
  • Nonspecific interstitial pneumonia
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Flaherty, K. R., Colby, T. V., Travis, W. D., Toews, G. B., Mumford, J., Murray, S., ... Martinez, F. J. (2003). Fibroblastic foci in usual interstitial pneumonia: Idiopathic versus collagen vascular disease. American Journal of Respiratory and Critical Care Medicine, 167(10), 1410-1415. https://doi.org/10.1164/rccm.200204-373OC

Fibroblastic foci in usual interstitial pneumonia : Idiopathic versus collagen vascular disease. / Flaherty, Kevin R.; Colby, Thomas V.; Travis, William D.; Toews, Galen B.; Mumford, Jeanette; Murray, Susan; Thannickal, Victor J.; Kazerooni, Ella A.; Gross, Barry H.; Lynch, Joseph P.; Martinez, Fernando J.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 167, No. 10, 15.05.2003, p. 1410-1415.

Research output: Contribution to journalArticle

Flaherty, KR, Colby, TV, Travis, WD, Toews, GB, Mumford, J, Murray, S, Thannickal, VJ, Kazerooni, EA, Gross, BH, Lynch, JP & Martinez, FJ 2003, 'Fibroblastic foci in usual interstitial pneumonia: Idiopathic versus collagen vascular disease', American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 10, pp. 1410-1415. https://doi.org/10.1164/rccm.200204-373OC
Flaherty, Kevin R. ; Colby, Thomas V. ; Travis, William D. ; Toews, Galen B. ; Mumford, Jeanette ; Murray, Susan ; Thannickal, Victor J. ; Kazerooni, Ella A. ; Gross, Barry H. ; Lynch, Joseph P. ; Martinez, Fernando J. / Fibroblastic foci in usual interstitial pneumonia : Idiopathic versus collagen vascular disease. In: American Journal of Respiratory and Critical Care Medicine. 2003 ; Vol. 167, No. 10. pp. 1410-1415.
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