Fibroblast growth factor signaling in liver carcinogenesis

Dalbir S. Sandhu; Esha Baichoo; Lewis R. Roberts

doi:10.1002/hep.26679

Fibroblast growth factor signaling in liver carcinogenesis

Dalbir S. Sandhu, Esha Baichoo, Lewis R. Roberts

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Fibroblast growth factors, or FGFs, are a large family of polypeptide cytokines exhibiting a pleiotropy of functions, from cell growth to angiogenesis, wound healing, and tissue repair. This review broadly covers the genetics and protein expression of the FGF family members and the signaling pathways involved in FGF-mediated growth regulation. We emphasize the role of FGFs in the pathogenesis of hepatocellular carcinoma (HCC), including their effects on regulation of the tumor microenvironment and angiogenesis. Finally, we present current views on FGF's potential role as a prognostic marker in clinical practice, as well as its potential as a therapeutic target in HCC. (Hepatology 2014;59:1166-1173)

Original language	English (US)
Pages (from-to)	1166-1173
Number of pages	8
Journal	Hepatology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1002/hep.26679
State	Published - Mar 2014

ASJC Scopus subject areas

Hepatology

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10.1002/hep.26679

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title = "Fibroblast growth factor signaling in liver carcinogenesis",

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year = "2014",

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AU - Baichoo, Esha

AU - Roberts, Lewis R.

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AB - Fibroblast growth factors, or FGFs, are a large family of polypeptide cytokines exhibiting a pleiotropy of functions, from cell growth to angiogenesis, wound healing, and tissue repair. This review broadly covers the genetics and protein expression of the FGF family members and the signaling pathways involved in FGF-mediated growth regulation. We emphasize the role of FGFs in the pathogenesis of hepatocellular carcinoma (HCC), including their effects on regulation of the tumor microenvironment and angiogenesis. Finally, we present current views on FGF's potential role as a prognostic marker in clinical practice, as well as its potential as a therapeutic target in HCC. (Hepatology 2014;59:1166-1173)

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Fibroblast growth factor signaling in liver carcinogenesis

Abstract

ASJC Scopus subject areas

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