Fibroblast growth factor signaling in liver carcinogenesis

Dalbir S. Sandhu, Esha Baichoo, Lewis Rowland Roberts

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Fibroblast growth factors, or FGFs, are a large family of polypeptide cytokines exhibiting a pleiotropy of functions, from cell growth to angiogenesis, wound healing, and tissue repair. This review broadly covers the genetics and protein expression of the FGF family members and the signaling pathways involved in FGF-mediated growth regulation. We emphasize the role of FGFs in the pathogenesis of hepatocellular carcinoma (HCC), including their effects on regulation of the tumor microenvironment and angiogenesis. Finally, we present current views on FGF's potential role as a prognostic marker in clinical practice, as well as its potential as a therapeutic target in HCC. (Hepatology 2014;59:1166-1173)

Original languageEnglish (US)
Pages (from-to)1166-1173
Number of pages8
JournalHepatology
Volume59
Issue number3
DOIs
StatePublished - Mar 2014

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Fibroblast Growth Factors
Hepatocellular Carcinoma
Carcinogenesis
Tumor Microenvironment
Liver
Gastroenterology
Growth
Wound Healing
Biomarkers
Cytokines
Peptides
Proteins
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Fibroblast growth factor signaling in liver carcinogenesis. / Sandhu, Dalbir S.; Baichoo, Esha; Roberts, Lewis Rowland.

In: Hepatology, Vol. 59, No. 3, 03.2014, p. 1166-1173.

Research output: Contribution to journalArticle

Sandhu, Dalbir S. ; Baichoo, Esha ; Roberts, Lewis Rowland. / Fibroblast growth factor signaling in liver carcinogenesis. In: Hepatology. 2014 ; Vol. 59, No. 3. pp. 1166-1173.
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