Abstract
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and a-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α-synuclein protein levels.
Original language | English (US) |
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Pages (from-to) | 455-459 |
Number of pages | 5 |
Journal | Movement Disorders |
Volume | 24 |
Issue number | 3 |
DOIs | |
State | Published - Feb 15 2009 |
Keywords
- Association study
- FGF20
- Genetics
- Parkinson's disease
- α-Synuclein
ASJC Scopus subject areas
- Neurology
- Clinical Neurology