Abstract
FGF10-FGFR2B signaling in bronchial epithelial stem cells is critical to drive both alveolar epithelial regeneration and the development of honeycomb cysts after bleomycin injury. Overexpression of Fgf10 in bronchial epithelial stem cells enhances fibrosis resolution by favoring the more desirable outcome of alveolar epithelial regeneration over the development of pathologic honeycomb cysts.
Original language | English (US) |
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Pages (from-to) | 1041-1055 |
Number of pages | 15 |
Journal | Stem Cell Reports |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - May 14 2019 |
Keywords
- Fgf signaling
- lung fibrosis
- lung regeneration
- lung stem cells
ASJC Scopus subject areas
- Biochemistry
- Genetics
- Developmental Biology
- Cell Biology