FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

Tingting Yuan, Thomas Volckaert, Elizabeth F. Redente, Seantel Hopkins, Kylie Klinkhammer, Roxana Wasnick, Cho Ming Chao, Jie Yuan, Jin San Zhang, Changfu Yao, Susan Majka, Barry R. Stripp, Andreas Günther, David W.H. Riches, Saverio Bellusci, Victor J. Thannickal, Stijn P. De Langhe

Research output: Contribution to journalArticlepeer-review

Abstract

FGF10-FGFR2B signaling in bronchial epithelial stem cells is critical to drive both alveolar epithelial regeneration and the development of honeycomb cysts after bleomycin injury. Overexpression of Fgf10 in bronchial epithelial stem cells enhances fibrosis resolution by favoring the more desirable outcome of alveolar epithelial regeneration over the development of pathologic honeycomb cysts.

Original languageEnglish (US)
Pages (from-to)1041-1055
Number of pages15
JournalStem Cell Reports
Volume12
Issue number5
DOIs
StatePublished - May 14 2019

Keywords

  • Fgf signaling
  • lung fibrosis
  • lung regeneration
  • lung stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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