Few-view and limited-angle cone-beam megavoltage CT for breast localization in radiation therapy

Lifeng Yu, Xiaochuan Pan, Charles A. Pelizzari, Mary Martel

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


In radiation therapy for breast cancer treatment, information about the external (skin) and internal (lung) boundaries is highly useful for determining the relative locations of the target and lung. In this work, we investigate the feasibility of tomographic reconstruction from few-view and limited-angle cone-beam projections acquired in radiation therapy unit for obtaining critical boundary information. From the few-view and limited-angle projections acquired directly in the treatment machine with an amorphous silicon electronic portal imaging device (EPID), We compared and evaluated the performance of the conventional cone-beam FDK algorithm and an iterative algorithm based upon the maximum-likelihood method for transmission tomography (ML-TR). Preliminary results demonstrated that the ML-TR algorithm is more promising than is the cone-beam FDK algorithm. Useful boundary information for breast localization can be obtained with very few projections in a limited angle range from the reconstruction of ML-TR algorithm.

Original languageEnglish (US)
Pages (from-to)2075-2082
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5370 III
StatePublished - Oct 27 2004
EventProgress in Biomedical Optics and Imaging - Medical Imaging 2004: Imaging Processing - San Diego, CA, United States
Duration: Feb 16 2004Feb 19 2004


  • Cone-beam ct
  • Megavoltage ct
  • Treatment verification

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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