Fetal thigh volume by 3D sonography using XI VOCAL: Reproducibility and reference range for BRAian healthy fetuses between 20 and 40weeks

Edward Araujo, Rafael Oliveira Cavalcante, Luciano Marcondes Machado Nardozza, Liliam Cristine Rolo, Rodrigo Ruano, Wellington de Paula Martins, Antonio Fernandes Moron

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: To provide reference values for fetal thigh volume using three-dimensional (3D) ultrasound and the eXtended Imaging Virtual Organ Computer-aided AnaLysis (XI VOCAL) method. Methods: This is a cross-sectional study that enrolled 425 healthy pregnant women between the 20 th and 40 th weeks of gestation. The XI VOCAL was performed along the axial cross-section in ten sequential areas for the volumetric calculations, having the proximal and distal echogenic diaphysis as references. Second-degree polynomial regression models, with the determination of percentiles, were created to evaluate the relation between the fetal thigh volume and gestational age (GA). Intraoperator and interoperator reproducibility was evaluated using intraclass correlation coefficient. Results: The mean fetal thigh volume varied from 8.00 (3.90-11.90cm 3) to 122.14cm 3 (105.0-153.50cm 3) at 20 and 40weeks of gestation, respectively. Fetal thigh volume was strongly correlated with gestational age, and the reference values can be obtained by the following mathematical equation: fetal thigh volume (cm 3)=68.70-7.63×GA+0.23×GA 2 (R 2=0.946). The intraoperator and interoperator reproducibility were excellent, with an intraclass correlation coefficient=1.000 and 0.999, respectively. Conclusions: The reference range of fetal thigh volume was determined by 3D-ultrasound using the XI VOCAL method.

Original languageEnglish (US)
Pages (from-to)1234-1240
Number of pages7
JournalPrenatal Diagnosis
Volume31
Issue number13
DOIs
StatePublished - Dec 1 2011

Keywords

  • Fetal 3D/4D ultrasound
  • Fetal thigh volume
  • Pregnancy
  • Reference range
  • Reproducibility
  • XI VOCAL method

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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    Araujo, E., Cavalcante, R. O., Nardozza, L. M. M., Rolo, L. C., Ruano, R., de Paula Martins, W., & Moron, A. F. (2011). Fetal thigh volume by 3D sonography using XI VOCAL: Reproducibility and reference range for BRAian healthy fetuses between 20 and 40weeks. Prenatal Diagnosis, 31(13), 1234-1240. https://doi.org/10.1002/pd.2870