Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes

Joshua A. Kailin, Gurpreet S. Dhillon, Shiraz A. Maskatia, Darrell L. Cass, Alireza A. Shamshirsaz, Amy R. Mehollin-Ray, Christopher I. Cassady, Nancy A. Ayres, Yunfei Wang, Michael A. Belfort, Oluyinka O. Olutoye, Rodrigo Ruano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left-sided cardiac structural dimensions, lung size, percentage liver herniation, lung-to-head ratio, postnatal left-sided cardiac structural dimensions, and postnatal outcomes. Methods: We performed a retrospective cohort study of fetuses with left-sided CDH who had prenatal echocardiographic, ultrasound, and magnetic resonance imaging examinations at our institution between January 2007 and March 2015. Postnatal outcomes assessed include use of inhaled nitric oxide (iNO), use of extracorporeal membrane oxygenation, and death. Results: Fifty-two fetuses with isolated left-sided CDH were included. Multivariate logistic regression models indicated that smaller fetal aortic valve z-score was associated with postnatal use of iNO (p = 0.03). Fetal mitral valve z-score correlated with lung-to-head ratio (p = 0.04), postnatal mitral valve z-score correlated with percent liver herniation (p = 0.03), and postnatal left ventricular end-diastolic dimension z-score correlated with liver herniation <20% (p = 0.04). Conclusion: We identified associations between smaller fetal left-sided cardiac structural dimensions and classic CDH indices. Smaller aortic valve z-score was associated with iNO use; however, left heart dimensions showed no association with extracorporeal membrane oxygenation or mortality. Further study into the impact of left-sided hypoplasia on outcomes in CDH is worthy of evaluation in a larger, prospective study.

Original languageEnglish (US)
Pages (from-to)502-509
Number of pages8
JournalPrenatal Diagnosis
Volume37
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

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Nitric Oxide
Extracorporeal Membrane Oxygenation
Fetus
Aortic Valve
Mitral Valve
Lung
Liver
Logistic Models
Head
Cohort Studies
Retrospective Studies
Magnetic Resonance Imaging
Congenital Diaphragmatic Hernias
Prospective Studies
Mortality

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

Cite this

Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes. / Kailin, Joshua A.; Dhillon, Gurpreet S.; Maskatia, Shiraz A.; Cass, Darrell L.; Shamshirsaz, Alireza A.; Mehollin-Ray, Amy R.; Cassady, Christopher I.; Ayres, Nancy A.; Wang, Yunfei; Belfort, Michael A.; Olutoye, Oluyinka O.; Ruano, Rodrigo.

In: Prenatal Diagnosis, Vol. 37, No. 5, 01.05.2017, p. 502-509.

Research output: Contribution to journalArticle

Kailin, JA, Dhillon, GS, Maskatia, SA, Cass, DL, Shamshirsaz, AA, Mehollin-Ray, AR, Cassady, CI, Ayres, NA, Wang, Y, Belfort, MA, Olutoye, OO & Ruano, R 2017, 'Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes', Prenatal Diagnosis, vol. 37, no. 5, pp. 502-509. https://doi.org/10.1002/pd.5045
Kailin, Joshua A. ; Dhillon, Gurpreet S. ; Maskatia, Shiraz A. ; Cass, Darrell L. ; Shamshirsaz, Alireza A. ; Mehollin-Ray, Amy R. ; Cassady, Christopher I. ; Ayres, Nancy A. ; Wang, Yunfei ; Belfort, Michael A. ; Olutoye, Oluyinka O. ; Ruano, Rodrigo. / Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes. In: Prenatal Diagnosis. 2017 ; Vol. 37, No. 5. pp. 502-509.
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abstract = "Objectives: Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left-sided cardiac structural dimensions, lung size, percentage liver herniation, lung-to-head ratio, postnatal left-sided cardiac structural dimensions, and postnatal outcomes. Methods: We performed a retrospective cohort study of fetuses with left-sided CDH who had prenatal echocardiographic, ultrasound, and magnetic resonance imaging examinations at our institution between January 2007 and March 2015. Postnatal outcomes assessed include use of inhaled nitric oxide (iNO), use of extracorporeal membrane oxygenation, and death. Results: Fifty-two fetuses with isolated left-sided CDH were included. Multivariate logistic regression models indicated that smaller fetal aortic valve z-score was associated with postnatal use of iNO (p = 0.03). Fetal mitral valve z-score correlated with lung-to-head ratio (p = 0.04), postnatal mitral valve z-score correlated with percent liver herniation (p = 0.03), and postnatal left ventricular end-diastolic dimension z-score correlated with liver herniation <20{\%} (p = 0.04). Conclusion: We identified associations between smaller fetal left-sided cardiac structural dimensions and classic CDH indices. Smaller aortic valve z-score was associated with iNO use; however, left heart dimensions showed no association with extracorporeal membrane oxygenation or mortality. Further study into the impact of left-sided hypoplasia on outcomes in CDH is worthy of evaluation in a larger, prospective study.",
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T1 - Fetal left-sided cardiac structural dimensions in left-sided congenital diaphragmatic hernia – association with severity and impact on postnatal outcomes

AU - Kailin, Joshua A.

AU - Dhillon, Gurpreet S.

AU - Maskatia, Shiraz A.

AU - Cass, Darrell L.

AU - Shamshirsaz, Alireza A.

AU - Mehollin-Ray, Amy R.

AU - Cassady, Christopher I.

AU - Ayres, Nancy A.

AU - Wang, Yunfei

AU - Belfort, Michael A.

AU - Olutoye, Oluyinka O.

AU - Ruano, Rodrigo

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objectives: Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left-sided cardiac structural dimensions, lung size, percentage liver herniation, lung-to-head ratio, postnatal left-sided cardiac structural dimensions, and postnatal outcomes. Methods: We performed a retrospective cohort study of fetuses with left-sided CDH who had prenatal echocardiographic, ultrasound, and magnetic resonance imaging examinations at our institution between January 2007 and March 2015. Postnatal outcomes assessed include use of inhaled nitric oxide (iNO), use of extracorporeal membrane oxygenation, and death. Results: Fifty-two fetuses with isolated left-sided CDH were included. Multivariate logistic regression models indicated that smaller fetal aortic valve z-score was associated with postnatal use of iNO (p = 0.03). Fetal mitral valve z-score correlated with lung-to-head ratio (p = 0.04), postnatal mitral valve z-score correlated with percent liver herniation (p = 0.03), and postnatal left ventricular end-diastolic dimension z-score correlated with liver herniation <20% (p = 0.04). Conclusion: We identified associations between smaller fetal left-sided cardiac structural dimensions and classic CDH indices. Smaller aortic valve z-score was associated with iNO use; however, left heart dimensions showed no association with extracorporeal membrane oxygenation or mortality. Further study into the impact of left-sided hypoplasia on outcomes in CDH is worthy of evaluation in a larger, prospective study.

AB - Objectives: Fetuses with congenital diaphragmatic hernia (CDH) demonstrate varying degrees of left heart hypoplasia. Our study assesses the relationship between fetal left-sided cardiac structural dimensions, lung size, percentage liver herniation, lung-to-head ratio, postnatal left-sided cardiac structural dimensions, and postnatal outcomes. Methods: We performed a retrospective cohort study of fetuses with left-sided CDH who had prenatal echocardiographic, ultrasound, and magnetic resonance imaging examinations at our institution between January 2007 and March 2015. Postnatal outcomes assessed include use of inhaled nitric oxide (iNO), use of extracorporeal membrane oxygenation, and death. Results: Fifty-two fetuses with isolated left-sided CDH were included. Multivariate logistic regression models indicated that smaller fetal aortic valve z-score was associated with postnatal use of iNO (p = 0.03). Fetal mitral valve z-score correlated with lung-to-head ratio (p = 0.04), postnatal mitral valve z-score correlated with percent liver herniation (p = 0.03), and postnatal left ventricular end-diastolic dimension z-score correlated with liver herniation <20% (p = 0.04). Conclusion: We identified associations between smaller fetal left-sided cardiac structural dimensions and classic CDH indices. Smaller aortic valve z-score was associated with iNO use; however, left heart dimensions showed no association with extracorporeal membrane oxygenation or mortality. Further study into the impact of left-sided hypoplasia on outcomes in CDH is worthy of evaluation in a larger, prospective study.

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