Fertility drug use and the risk of ovarian tumors in infertile women: A case-control study

Albert Asante, Phoebe H. Leonard, Amy L. Weaver, Ellen L Goode, Jani R. Jensen, Elizabeth A Stewart, Charles C. Coddington

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: To assess the influence of infertility and fertility drugs on risk of ovarian tumors. Design: Case-control study (Mayo Clinic Ovarian Cancer Study). Setting: Ongoing academic study of ovarian cancer. Patient(s): A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use. Intervention(s): None. Main Outcome Measure(s): Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders. Result(s): Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. Conclusion(s): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.

Original languageEnglish (US)
Pages (from-to)2031-2036
Number of pages6
JournalFertility and Sterility
Volume99
Issue number7
DOIs
StatePublished - Jun 2013

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Fertility Agents
Case-Control Studies
Neoplasms
Gravidity
Ovarian Neoplasms
Infertility
Contraception
Self Report
Odds Ratio
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Borderline tumors
  • case control
  • fertility drugs
  • ovarian tumors
  • primary infertility

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Fertility drug use and the risk of ovarian tumors in infertile women : A case-control study. / Asante, Albert; Leonard, Phoebe H.; Weaver, Amy L.; Goode, Ellen L; Jensen, Jani R.; Stewart, Elizabeth A; Coddington, Charles C.

In: Fertility and Sterility, Vol. 99, No. 7, 06.2013, p. 2031-2036.

Research output: Contribution to journalArticle

Asante, Albert ; Leonard, Phoebe H. ; Weaver, Amy L. ; Goode, Ellen L ; Jensen, Jani R. ; Stewart, Elizabeth A ; Coddington, Charles C. / Fertility drug use and the risk of ovarian tumors in infertile women : A case-control study. In: Fertility and Sterility. 2013 ; Vol. 99, No. 7. pp. 2031-2036.
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