Female Gender Is Associated with Impaired Quality of Life 1 Year after Coronary Artery Bypass Surgery

Barbara Phillips Bute, Joseph Mathew, James A. Blumenthal, Kathleen Welsh-Bohmer, William D. White, Daniel Mark, Kevin Landolfo, Mark F. Newman

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. Materials and Methods. Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year after CABG. Multivariable linear regression was used to assess the relationship of gender to follow-up QOL and cognitive function. Measures used to evaluate QOL were IADL, DASI, work activities (SF-36), social activities, social support, general health perception (SF-36), CESD, STAI, and symptom limitations. Cognitive function was measured with a battery of performance-based neuropsychological tests, reduced to a four-cognitive domain scores with factor analysis, and a self-report measure of cognitive difficulties. Covariates in multiple regression models included age, years of education, marital status, Charlson Comorbidity Index, hypertension, diabetes, race, and baseline QOL/cognitive status. Results: Female patients showed significantly worse outcome than male patients at 1 year follow-up in several key areas of QOL. After adjusting for baseline differences, women are at greater risk for increased cognitive difficulties (p = 0.04) and anxiety (p = 0.03), as well as impaired DASI (p = 0.02), IADL (p = 0.03), and work activities (p = 0.02). Cognitive sequelae attributable to bypass surgery were similar between men and women. Conclusions: Even after adjusting for known risk factors for compromised QOL and cognitive functioning, women do not show the same long-term quality benefits of CABG surgery that men do.

Original languageEnglish (US)
Pages (from-to)944-951
Number of pages8
JournalPsychosomatic Medicine
Volume65
Issue number6
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Coronary Artery Bypass
Quality of Life
Cognition
Neuropsychological Tests
Marital Status
Surgery
Social Support
Self Report
Statistical Factor Analysis
Comorbidity
Linear Models
Anxiety
Hypertension
Education
Health
Cognitive Function

Keywords

  • CABG surgery
  • Cognitive function
  • Gender
  • Quality of life

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Bute, B. P., Mathew, J., Blumenthal, J. A., Welsh-Bohmer, K., White, W. D., Mark, D., ... Newman, M. F. (2003). Female Gender Is Associated with Impaired Quality of Life 1 Year after Coronary Artery Bypass Surgery. Psychosomatic Medicine, 65(6), 944-951. https://doi.org/10.1097/01.PSY.0000097342.24933.A2

Female Gender Is Associated with Impaired Quality of Life 1 Year after Coronary Artery Bypass Surgery. / Bute, Barbara Phillips; Mathew, Joseph; Blumenthal, James A.; Welsh-Bohmer, Kathleen; White, William D.; Mark, Daniel; Landolfo, Kevin; Newman, Mark F.

In: Psychosomatic Medicine, Vol. 65, No. 6, 11.2003, p. 944-951.

Research output: Contribution to journalArticle

Bute, BP, Mathew, J, Blumenthal, JA, Welsh-Bohmer, K, White, WD, Mark, D, Landolfo, K & Newman, MF 2003, 'Female Gender Is Associated with Impaired Quality of Life 1 Year after Coronary Artery Bypass Surgery', Psychosomatic Medicine, vol. 65, no. 6, pp. 944-951. https://doi.org/10.1097/01.PSY.0000097342.24933.A2
Bute, Barbara Phillips ; Mathew, Joseph ; Blumenthal, James A. ; Welsh-Bohmer, Kathleen ; White, William D. ; Mark, Daniel ; Landolfo, Kevin ; Newman, Mark F. / Female Gender Is Associated with Impaired Quality of Life 1 Year after Coronary Artery Bypass Surgery. In: Psychosomatic Medicine. 2003 ; Vol. 65, No. 6. pp. 944-951.
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abstract = "Objective: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. Materials and Methods. Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year after CABG. Multivariable linear regression was used to assess the relationship of gender to follow-up QOL and cognitive function. Measures used to evaluate QOL were IADL, DASI, work activities (SF-36), social activities, social support, general health perception (SF-36), CESD, STAI, and symptom limitations. Cognitive function was measured with a battery of performance-based neuropsychological tests, reduced to a four-cognitive domain scores with factor analysis, and a self-report measure of cognitive difficulties. Covariates in multiple regression models included age, years of education, marital status, Charlson Comorbidity Index, hypertension, diabetes, race, and baseline QOL/cognitive status. Results: Female patients showed significantly worse outcome than male patients at 1 year follow-up in several key areas of QOL. After adjusting for baseline differences, women are at greater risk for increased cognitive difficulties (p = 0.04) and anxiety (p = 0.03), as well as impaired DASI (p = 0.02), IADL (p = 0.03), and work activities (p = 0.02). Cognitive sequelae attributable to bypass surgery were similar between men and women. Conclusions: Even after adjusting for known risk factors for compromised QOL and cognitive functioning, women do not show the same long-term quality benefits of CABG surgery that men do.",
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AB - Objective: To evaluate gender-related differences in quality of life (QOL) and cognitive function 1 year after coronary artery bypass surgery (CABG) after adjusting for known baseline differences. Materials and Methods. Two hundred eighty patients (96 women and 184 men) underwent neurocognitive and QOL evaluation at baseline (preoperatively) and at 1 year after CABG. Multivariable linear regression was used to assess the relationship of gender to follow-up QOL and cognitive function. Measures used to evaluate QOL were IADL, DASI, work activities (SF-36), social activities, social support, general health perception (SF-36), CESD, STAI, and symptom limitations. Cognitive function was measured with a battery of performance-based neuropsychological tests, reduced to a four-cognitive domain scores with factor analysis, and a self-report measure of cognitive difficulties. Covariates in multiple regression models included age, years of education, marital status, Charlson Comorbidity Index, hypertension, diabetes, race, and baseline QOL/cognitive status. Results: Female patients showed significantly worse outcome than male patients at 1 year follow-up in several key areas of QOL. After adjusting for baseline differences, women are at greater risk for increased cognitive difficulties (p = 0.04) and anxiety (p = 0.03), as well as impaired DASI (p = 0.02), IADL (p = 0.03), and work activities (p = 0.02). Cognitive sequelae attributable to bypass surgery were similar between men and women. Conclusions: Even after adjusting for known risk factors for compromised QOL and cognitive functioning, women do not show the same long-term quality benefits of CABG surgery that men do.

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