Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus

Yasuhiro Takeuchi, Richard Geoffrey Vile, Guy Simpson, Bryan O'Hara, Mary K L Collins, Robin A. Weiss

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Pseudotypes of gibbon ape leukemia virus/simian sarcoma-associated virus (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B) have been constructed by rescuing a Moloney murine leukemia virus vector genome with wild-type GALV/SSAV or FeLV-B. The resulting recombinant viruses utilized core and envelope proteins from the wild-type virus and conferred resistance to growth in é-histidinol upon infected cells by virtue of the HisD gene encoded by the vector genome. They displayed the host range specificity of the rescuing viruses and could be neutralized by virus-specific antisera. Receptor cross-interference was observed when the GALV/SSAV or FeLV-B pseudotypes were used to superinfect cells productively infected with either GALV/SSAV or FeLV-B. Although murine cells are resistant to FeLV-B infection, murine cells expressing the human gene for the GALV/SSAV receptor became susceptible to FeLV-B infection. Therefore GALV/SSAV and FeLV-B utilize the same cell surface receptor.

Original languageEnglish (US)
Pages (from-to)1219-1222
Number of pages4
JournalJournal of Virology
Volume66
Issue number2
StatePublished - Feb 1992
Externally publishedYes

Fingerprint

Gibbon ape leukemia virus
Woolly Monkey Sarcoma Virus
Feline Leukemia Virus
Feline leukemia virus
Satellite Viruses
Cell Surface Receptors
sarcoma
viruses
receptors
cells
Host Specificity
Viruses
Histidinol
Genome
Viral Core Proteins
Viral Envelope Proteins
Moloney murine leukemia virus
Virus Receptors
Murine leukemia virus
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Takeuchi, Y., Vile, R. G., Simpson, G., O'Hara, B., Collins, M. K. L., & Weiss, R. A. (1992). Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. Journal of Virology, 66(2), 1219-1222.

Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. / Takeuchi, Yasuhiro; Vile, Richard Geoffrey; Simpson, Guy; O'Hara, Bryan; Collins, Mary K L; Weiss, Robin A.

In: Journal of Virology, Vol. 66, No. 2, 02.1992, p. 1219-1222.

Research output: Contribution to journalArticle

Takeuchi, Y, Vile, RG, Simpson, G, O'Hara, B, Collins, MKL & Weiss, RA 1992, 'Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus', Journal of Virology, vol. 66, no. 2, pp. 1219-1222.
Takeuchi Y, Vile RG, Simpson G, O'Hara B, Collins MKL, Weiss RA. Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. Journal of Virology. 1992 Feb;66(2):1219-1222.
Takeuchi, Yasuhiro ; Vile, Richard Geoffrey ; Simpson, Guy ; O'Hara, Bryan ; Collins, Mary K L ; Weiss, Robin A. / Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. In: Journal of Virology. 1992 ; Vol. 66, No. 2. pp. 1219-1222.
@article{4bc11ef21f4e4a72b08c44c33a355fd6,
title = "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus",
abstract = "Pseudotypes of gibbon ape leukemia virus/simian sarcoma-associated virus (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B) have been constructed by rescuing a Moloney murine leukemia virus vector genome with wild-type GALV/SSAV or FeLV-B. The resulting recombinant viruses utilized core and envelope proteins from the wild-type virus and conferred resistance to growth in {\'e}-histidinol upon infected cells by virtue of the HisD gene encoded by the vector genome. They displayed the host range specificity of the rescuing viruses and could be neutralized by virus-specific antisera. Receptor cross-interference was observed when the GALV/SSAV or FeLV-B pseudotypes were used to superinfect cells productively infected with either GALV/SSAV or FeLV-B. Although murine cells are resistant to FeLV-B infection, murine cells expressing the human gene for the GALV/SSAV receptor became susceptible to FeLV-B infection. Therefore GALV/SSAV and FeLV-B utilize the same cell surface receptor.",
author = "Yasuhiro Takeuchi and Vile, {Richard Geoffrey} and Guy Simpson and Bryan O'Hara and Collins, {Mary K L} and Weiss, {Robin A.}",
year = "1992",
month = "2",
language = "English (US)",
volume = "66",
pages = "1219--1222",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus

AU - Takeuchi, Yasuhiro

AU - Vile, Richard Geoffrey

AU - Simpson, Guy

AU - O'Hara, Bryan

AU - Collins, Mary K L

AU - Weiss, Robin A.

PY - 1992/2

Y1 - 1992/2

N2 - Pseudotypes of gibbon ape leukemia virus/simian sarcoma-associated virus (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B) have been constructed by rescuing a Moloney murine leukemia virus vector genome with wild-type GALV/SSAV or FeLV-B. The resulting recombinant viruses utilized core and envelope proteins from the wild-type virus and conferred resistance to growth in é-histidinol upon infected cells by virtue of the HisD gene encoded by the vector genome. They displayed the host range specificity of the rescuing viruses and could be neutralized by virus-specific antisera. Receptor cross-interference was observed when the GALV/SSAV or FeLV-B pseudotypes were used to superinfect cells productively infected with either GALV/SSAV or FeLV-B. Although murine cells are resistant to FeLV-B infection, murine cells expressing the human gene for the GALV/SSAV receptor became susceptible to FeLV-B infection. Therefore GALV/SSAV and FeLV-B utilize the same cell surface receptor.

AB - Pseudotypes of gibbon ape leukemia virus/simian sarcoma-associated virus (GALV/SSAV) and feline leukemia virus subgroup B (FeLV-B) have been constructed by rescuing a Moloney murine leukemia virus vector genome with wild-type GALV/SSAV or FeLV-B. The resulting recombinant viruses utilized core and envelope proteins from the wild-type virus and conferred resistance to growth in é-histidinol upon infected cells by virtue of the HisD gene encoded by the vector genome. They displayed the host range specificity of the rescuing viruses and could be neutralized by virus-specific antisera. Receptor cross-interference was observed when the GALV/SSAV or FeLV-B pseudotypes were used to superinfect cells productively infected with either GALV/SSAV or FeLV-B. Although murine cells are resistant to FeLV-B infection, murine cells expressing the human gene for the GALV/SSAV receptor became susceptible to FeLV-B infection. Therefore GALV/SSAV and FeLV-B utilize the same cell surface receptor.

UR - http://www.scopus.com/inward/record.url?scp=0026512199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026512199&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 1219

EP - 1222

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 2

ER -