Feeling the squeeze: Does airway constriction stimulate the bronchial epithelium?

D. J. Tschumperlin, J. M. Drazen

Research output: Contribution to journalConference article

Abstract

Bronchospasm is a frequent occurrence in the airways of asthmatics, and subjects the bronchial epithelium to compressive stress. We show here that compressive stresses similar to those occurring in vivo trigger human bronchial epithelial cells to release endothelin (ET) and transforming growth factor-β2 (TGF-β2). Compressive stress leads to an increase in the steady state level of mRNA for both ET-1 and ET-2, and to the release of TGF-β2 from a pre-formed, cell-associated pool. We also show that ET-2 and TGF-β2 stimulate fibrotic protein synthesis by human lung fibroblasts, and act synergistically in combination. Our results demonstrate that compressive stress elicits selective release of fibrotic mediators from bronchial epithelium, indicating that bronchospasm may contribute to the subepithelial fibrosis and airways remodeling that characterize asthma.

Original languageEnglish (US)
Pages (from-to)1468-1469
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Asthma
  • Compressive stress
  • Fibrosis
  • Mechanotransduction

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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