Feed-forward inhibition: A novel cellular mechanism for the analgesic effect of substance P

Long Jun Wu, Hui Xu, Shanelle W. Ko, Megumu Yoshimura, Min Zhuo

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feedforward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.

Original languageEnglish (US)
Article number34
JournalMolecular Pain
Volume1
DOIs
StatePublished - Nov 18 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Cellular and Molecular Neuroscience
  • Anesthesiology and Pain Medicine

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