Fecal excretion of hepatitis A virus in humans

Jorge Rakela, J. W. Mosley

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To define more completely the period of fecal excretion of virus during hepatitis A virus infection, the authors studied 24 fecal samples from six children with clinical illness durng an epidemic of type A hepatitis. As determined by immune electron microscopy, the six patients had detectable viral excretion before or by the time of the first abnormality in serum glutamic-pyruvic transaminase (alanine aminotransferase). Viral excretion reached a peak early and declined to undetectable levels before levels of serum enzyme reached a peak. These data accord with epidemiologic evidence that the person who already has symptoms and signs of type A hepatitis is unlikely to transmit the infection to others. Immune electron microscopy, therefore, may be a better index to the period of communicability than studies of experimental infection in human subjects. This conclusion would imply that precautions against fecal contamination are not usually necessary for patients hospitalized with type A hepatitis.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalJournal of Infectious Diseases
Volume135
Issue number6
StatePublished - 1977
Externally publishedYes

Fingerprint

Human hepatitis A virus
Hepatitis
Alanine Transaminase
Electron Microscopy
Hepatitis A virus
Virus Diseases
Infection
Serum
Signs and Symptoms
Viruses
Enzymes

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Fecal excretion of hepatitis A virus in humans. / Rakela, Jorge; Mosley, J. W.

In: Journal of Infectious Diseases, Vol. 135, No. 6, 1977, p. 933-938.

Research output: Contribution to journalArticle

Rakela, Jorge ; Mosley, J. W. / Fecal excretion of hepatitis A virus in humans. In: Journal of Infectious Diseases. 1977 ; Vol. 135, No. 6. pp. 933-938.
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