TY - JOUR
T1 - Fecal excretion of hepatitis A virus in humans
AU - Rakela, J.
AU - Mosley, J. W.
PY - 1977
Y1 - 1977
N2 - To define more completely the period of fecal excretion of virus during hepatitis A virus infection, the authors studied 24 fecal samples from six children with clinical illness durng an epidemic of type A hepatitis. As determined by immune electron microscopy, the six patients had detectable viral excretion before or by the time of the first abnormality in serum glutamic-pyruvic transaminase (alanine aminotransferase). Viral excretion reached a peak early and declined to undetectable levels before levels of serum enzyme reached a peak. These data accord with epidemiologic evidence that the person who already has symptoms and signs of type A hepatitis is unlikely to transmit the infection to others. Immune electron microscopy, therefore, may be a better index to the period of communicability than studies of experimental infection in human subjects. This conclusion would imply that precautions against fecal contamination are not usually necessary for patients hospitalized with type A hepatitis.
AB - To define more completely the period of fecal excretion of virus during hepatitis A virus infection, the authors studied 24 fecal samples from six children with clinical illness durng an epidemic of type A hepatitis. As determined by immune electron microscopy, the six patients had detectable viral excretion before or by the time of the first abnormality in serum glutamic-pyruvic transaminase (alanine aminotransferase). Viral excretion reached a peak early and declined to undetectable levels before levels of serum enzyme reached a peak. These data accord with epidemiologic evidence that the person who already has symptoms and signs of type A hepatitis is unlikely to transmit the infection to others. Immune electron microscopy, therefore, may be a better index to the period of communicability than studies of experimental infection in human subjects. This conclusion would imply that precautions against fecal contamination are not usually necessary for patients hospitalized with type A hepatitis.
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U2 - 10.1093/infdis/135.6.933
DO - 10.1093/infdis/135.6.933
M3 - Article
C2 - 193999
AN - SCOPUS:0017702224
SN - 0022-1899
VL - 135
SP - 933
EP - 938
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -