Fecal excretion of hepatitis A virus in humans

J. Rakela, J. W. Mosley

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

To define more completely the period of fecal excretion of virus during hepatitis A virus infection, the authors studied 24 fecal samples from six children with clinical illness durng an epidemic of type A hepatitis. As determined by immune electron microscopy, the six patients had detectable viral excretion before or by the time of the first abnormality in serum glutamic-pyruvic transaminase (alanine aminotransferase). Viral excretion reached a peak early and declined to undetectable levels before levels of serum enzyme reached a peak. These data accord with epidemiologic evidence that the person who already has symptoms and signs of type A hepatitis is unlikely to transmit the infection to others. Immune electron microscopy, therefore, may be a better index to the period of communicability than studies of experimental infection in human subjects. This conclusion would imply that precautions against fecal contamination are not usually necessary for patients hospitalized with type A hepatitis.

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalJournal of Infectious Diseases
Volume135
Issue number6
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Fecal excretion of hepatitis A virus in humans'. Together they form a unique fingerprint.

  • Cite this