Features of Cardiac Allograft Coronary Endothelial Dysfunction

Eugenia Raichlin, Sudhir S. Kushwaha, Ryan J. Lennon, Robert Frantz, Brooks Sayre Edwards, Abhiram Prasad, Charanjit S. Rihal, Amir Lerman

Research output: Contribution to journalArticle

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Abstract

The aim of the study was to evaluate the features and mechanism of cardiac allograft coronary endothelial dysfunction. Coronary blood flow and epicardial coronary artery diameter response to intracoronary acetylcholine and NG-monomethyl-l-arginine were assessed in 19 cyclosporine-treated heart transplant recipients with normal coronary angiograms (3.8 ± 2.3 years after transplantation) and compared with 19 age-, gender-, and cardiovascular risk factor-matched nontransplantation control patients with normal coronary angiograms. Heart transplant recipients had more epicardial vasoconstriction in response to intracoronary acetylcholine (mean -16 ± 19% [SD] vs 4 ± 10%; p = 0.036). Microvascular endothelial function was similar between groups. Coronary flow reserve in response to adenosine was higher in the transplant group (3.6 ± 0.8 vs 3.1 ± 0.7; p = 0.04). The effect of NG-monomethyl-l-arginine (64 μmol/min) on coronary blood flow (-16 ± 21% vs -37 ± 19%; p = 0.018), coronary artery diameter (-10 ± 13% vs -21 ± 11%; p = 0.04), and coronary vascular resistance (34 ± 40% vs 73 ± 63%; p = 0.047) was significantly attenuated in the transplant group compared with controls. In conclusion, cardiac allograft epicardial coronary endothelial function was abnormal and may be related to an impaired endogenous NO synthetase pathway and reduced endothelial nitric oxide production in transplant recipients.

Original languageEnglish (US)
Pages (from-to)1154-1158
Number of pages5
JournalAmerican Journal of Cardiology
Volume103
Issue number8
DOIs
StatePublished - Apr 15 2009

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Allografts
Acetylcholine
Arginine
Coronary Vessels
Angiography
Transplants
Ligases
Vasoconstriction
Vascular Resistance
Adenosine
Cyclosporine
Nitric Oxide
Transplantation
Transplant Recipients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Features of Cardiac Allograft Coronary Endothelial Dysfunction. / Raichlin, Eugenia; Kushwaha, Sudhir S.; Lennon, Ryan J.; Frantz, Robert; Edwards, Brooks Sayre; Prasad, Abhiram; Rihal, Charanjit S.; Lerman, Amir.

In: American Journal of Cardiology, Vol. 103, No. 8, 15.04.2009, p. 1154-1158.

Research output: Contribution to journalArticle

Raichlin, Eugenia ; Kushwaha, Sudhir S. ; Lennon, Ryan J. ; Frantz, Robert ; Edwards, Brooks Sayre ; Prasad, Abhiram ; Rihal, Charanjit S. ; Lerman, Amir. / Features of Cardiac Allograft Coronary Endothelial Dysfunction. In: American Journal of Cardiology. 2009 ; Vol. 103, No. 8. pp. 1154-1158.
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