Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams

H. Immo Lehmann, Christian Graeff, Palma Simoniello, Anna Constantinescu, Mitsuru Takami, Patrick Lugenbiel, Daniel Richter, Anna Eichhorn, Matthias Prall, Robert Kaderka, Fine Fiedler, Stephan Helmbrecht, Claudia Fournier, Nadine Erbeldinger, Ann Kathrin Rahm, Rasmus Rivinius, Dierk Thomas, Hugo A. Katus, Susan B. Johnson, Kay D. ParkerJürgen Debus, Samuel J. Asirvatham, Christoph Bert, Marco Durante, Douglas L. Packer

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction.

Original languageEnglish (US)
Article number38895
JournalScientific reports
Volume6
DOIs
StatePublished - Dec 20 2016

ASJC Scopus subject areas

  • General

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