Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation

Zahra Aghababaie, Chih Hsiang Alexander Chan, Niranchan Paskaranandavadivel, Arthur Beyder, Gianrico Farrugia, Samuel Asirvatham, Gregory O'Grady, Leo K. Cheng, Timothy R. Angeli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interstitial cells of Cajal (ICC) initiate, coordinate and propagate bioelectrical slow wave activity that drives gastric motility. In the healthy human stomach, slow wave activity is highly organized. Gastric motility disorders are associated with dysrhythmias. While ablation is widely used to treat cardiac dysrhythmias, this approach has yet to be trialed in the stomach. In this study, radiofrequency (RF) ablation was applied in pig stomachs in vivo to create targeted electrical conduction blocks. Ablations were performed at temperature control mode (55-70°C), and resultant conduction blocks were identified and verified using high-resolution electrical mapping. Termination of slow wave propagation at ablation sites was confirmed by a decrease in extracellular slow wave amplitude from 1.7 ± 0.2 mV to an undetectable amplitude, as well as spatiotemporal pattern analysis of conduction blocks. The use of high-resolution electrical mapping can now be employed to investigate ablation as a potential therapy for gastric dysrhythmias in motility disorders.

Original languageEnglish (US)
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages170-173
Number of pages4
ISBN (Electronic)9781538613115
DOIs
StatePublished - Jul 2019
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany
Duration: Jul 23 2019Jul 27 2019

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
CountryGermany
CityBerlin
Period7/23/197/27/19

Fingerprint

Ablation
Stomach
Interstitial Cells of Cajal
Spatio-Temporal Analysis
Temperature control
Wave propagation
Cells
Cardiac Arrhythmias
Swine
Temperature

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Aghababaie, Z., Chan, C. H. A., Paskaranandavadivel, N., Beyder, A., Farrugia, G., Asirvatham, S., ... Angeli, T. R. (2019). Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 170-173). [8856406] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8856406

Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. / Aghababaie, Zahra; Chan, Chih Hsiang Alexander; Paskaranandavadivel, Niranchan; Beyder, Arthur; Farrugia, Gianrico; Asirvatham, Samuel; O'Grady, Gregory; Cheng, Leo K.; Angeli, Timothy R.

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 170-173 8856406 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Aghababaie, Z, Chan, CHA, Paskaranandavadivel, N, Beyder, A, Farrugia, G, Asirvatham, S, O'Grady, G, Cheng, LK & Angeli, TR 2019, Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856406, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 170-173, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Germany, 7/23/19. https://doi.org/10.1109/EMBC.2019.8856406
Aghababaie Z, Chan CHA, Paskaranandavadivel N, Beyder A, Farrugia G, Asirvatham S et al. Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 170-173. 8856406. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2019.8856406
Aghababaie, Zahra ; Chan, Chih Hsiang Alexander ; Paskaranandavadivel, Niranchan ; Beyder, Arthur ; Farrugia, Gianrico ; Asirvatham, Samuel ; O'Grady, Gregory ; Cheng, Leo K. ; Angeli, Timothy R. / Feasibility of High-Resolution Electrical Mapping for Characterizing Conduction Blocks Created by Gastric Ablation. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 170-173 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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