@inproceedings{c659c428f15242b08ee8c40b51591547,
title = "Feasibility of fabricating personalized 3D-printed bone grafts guided by high-resolution imaging",
abstract = "Current methods of bone graft treatment for critical size bone defects can give way to several clinical complications such as limited available bone for autografts, non-matching bone structure, lack of strength which can compromise a patient's skeletal system, and sterilization processes that can prevent osteogenesis in the case of allografts. We intend to overcome these disadvantages by generating a patient-specific 3D printed bone graft guided by high-resolution medical imaging. Our synthetic model allows us to customize the graft for the patients' macro- and microstructure and correct any structural deficiencies in the re-meshing process. These 3D-printed models can presumptively serve as the scaffolding for human mesenchymal stem cell (hMSC) engraftment in order to facilitate bone growth. We performed highresolution CT imaging of a cadaveric human proximal femur at 0.030-mm isotropic voxels. We used these images to generate a 3D computer model that mimics bone geometry from micro to macro scale represented by STereoLithography (STL) format. These models were then reformatted to a format that can be interpreted by the 3D printer. To assess how much of the microstructure was replicated, 3D-printed models were re-imaged using micro-CT at 0.025-mm isotropic voxels and compared to original high-resolution CT images used to generate the 3D model in 32 sub-regions. We found a strong correlation between 3D-printed bone volume and volume of bone in the original images used for 3D printing (R2 = 0.97). We expect to further refine our approach with additional testing to create a viable synthetic bone graft with clinical functionality.",
keywords = "3D printing, Bone grafts, Critical size bone defects, High-resolution imaging, Human mesenchymal stem cells, Polycaprolactone, Proximal femur, STereoLithography",
author = "Hong, {Abigail L.} and Newman, {Benjamin T.} and Arbab Khalid and Teter, {Olivia M.} and Kobe, {Elizabeth A.} and Malika Shukurova and Rohit Shinde and Daniel Sipzner and Pignolo, {Robert J.} and Udupa, {Jayaram K.} and Rajapakse, {Chamith S.}",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; Medical Imaging 2017: Imaging Informatics for Healthcare, Research, and Applications ; Conference date: 15-02-2017 Through 16-02-2017",
year = "2017",
doi = "10.1117/12.2254475",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Cook, {Tessa S.} and Jianguo Zhang",
booktitle = "Medical Imaging 2017",
}