TY - JOUR
T1 - Feasibility of discriminating uric acid from non-uric acid renal stones using consecutive spatially registered low-and high-energy scans obtained on a conventional CT scanner
AU - Leng, Shuai
AU - Shiung, Maria
AU - Ai, Songtao
AU - Qu, Mingliang
AU - Vrtiska, Terri J.
AU - Grant, Katharine L.
AU - Krauss, Bernhard
AU - Schmidt, Bernhard
AU - Lieske, John C.
AU - McCollough, Cynthia H.
N1 - Publisher Copyright:
© American Roentgen Ray Society.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - OBJECTIVE The objective of our study was to show the feasibility of distinguishing between uric acid (UA) and non-UA renal stones using two consecutive spatially registered low-and high-energy scans acquired on a conventional CT system. SUBJECTS AND METHODS. A total of 33 patients undergoing clinically indicated dual-source dual-energy CT examinations to differentiate UA from non-UA renal stones were enrolled in this study. Immediately after patients underwent clinically indicated dual-source dual-energy CT, two consecutive scans (one at 80 kV and one at 140 kV) were obtained on a conventional CT scanner over the region limited to the stones identified on the dual-source scans. After 3D deformable registration of the 80-and 140-kV images, UA and non-UA stones were identified using commercial software. The sensitivity, specificity, and accuracy of stone classification were calculated using the dual-source results as the reference standard. RESULTS. A total of 469 stones were identified in the dual-source examinations (26 UA and 443 non-UA stones). The average in-plane stone diameter was 4.4 ± 2.5 (SD) mm (range, 2.0-18.9 mm). The overall sensitivity, specificity, and accuracy for identifying UA stones were 73.1%, 90.1%, and 89.1%, respectively. The sensitivity, specificity, and accuracy were 94.7%, 96.9%, and 96.8% for stones 3 mm or larger (n = 341[19 UA and 322 non-UA]). CONCLUSION. Accurate differentiation of UA from non-UA renal stones is feasible using two consecutively acquired and spatially registered conventional CT scans.
AB - OBJECTIVE The objective of our study was to show the feasibility of distinguishing between uric acid (UA) and non-UA renal stones using two consecutive spatially registered low-and high-energy scans acquired on a conventional CT system. SUBJECTS AND METHODS. A total of 33 patients undergoing clinically indicated dual-source dual-energy CT examinations to differentiate UA from non-UA renal stones were enrolled in this study. Immediately after patients underwent clinically indicated dual-source dual-energy CT, two consecutive scans (one at 80 kV and one at 140 kV) were obtained on a conventional CT scanner over the region limited to the stones identified on the dual-source scans. After 3D deformable registration of the 80-and 140-kV images, UA and non-UA stones were identified using commercial software. The sensitivity, specificity, and accuracy of stone classification were calculated using the dual-source results as the reference standard. RESULTS. A total of 469 stones were identified in the dual-source examinations (26 UA and 443 non-UA stones). The average in-plane stone diameter was 4.4 ± 2.5 (SD) mm (range, 2.0-18.9 mm). The overall sensitivity, specificity, and accuracy for identifying UA stones were 73.1%, 90.1%, and 89.1%, respectively. The sensitivity, specificity, and accuracy were 94.7%, 96.9%, and 96.8% for stones 3 mm or larger (n = 341[19 UA and 322 non-UA]). CONCLUSION. Accurate differentiation of UA from non-UA renal stones is feasible using two consecutively acquired and spatially registered conventional CT scans.
KW - CT
KW - Deformable registration
KW - Dual-energy CT
KW - Renal stone
KW - Stone composition
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U2 - 10.2214/AJR.13.11911
DO - 10.2214/AJR.13.11911
M3 - Article
C2 - 25539242
AN - SCOPUS:84928573542
SN - 0361-803X
VL - 204
SP - 92
EP - 97
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 1
ER -