Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

Anne Marie Lennon; Adam H. Buchanan; Isaac Kinde; Andrew Warren; Ashley Honushefsky; Ariella T. Cohain; David H. Ledbetter; Fred Sanfilippo; Kathleen Sheridan; Dillenia Rosica; Christian S. Adonizio; Hee Jung Hwang; Kamel Lahouel; Joshua D. Cohen; Christopher Douville; Aalpen A. Pate; Leonardo N. Hagmann; David D. Rolston; Nirav Malani; Shibin Zhou; Chetan Bettegowda; David L. Diehl; Bobbi Urban; Christopher D. Still; Lisa Kann; Julie I. Woods; Zachary M. Salvati; Joseph Vadakara; Rosemary Leeming; Prianka Bhattacharya; Carroll Walter; Alex Parker; Christoph Lengauer; Alison Klein; Cristian Tomasetti; Elliot K. Fishman; Ralph H. Hruban; Kenneth W. Kinzler; Bert Vogelstein; Nickolas Papadopoulos

doi:10.1126/science.abb9601

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

Anne Marie Lennon, Adam H. Buchanan, Isaac Kinde, Andrew Warren, Ashley Honushefsky, Ariella T. Cohain, David H. Ledbetter, Fred Sanfilippo, Kathleen Sheridan, Dillenia Rosica, Christian S. Adonizio, Hee Jung Hwang, Kamel Lahouel, Joshua D. Cohen, Christopher Douville, Aalpen A. Pate, Leonardo N. Hagmann, David D. Rolston, Nirav Malani, Shibin ZhouChetan Bettegowda, David L. Diehl, Bobbi Urban, Christopher D. Still, Lisa Kann, Julie I. Woods, Zachary M. Salvati, Joseph Vadakara, Rosemary Leeming, Prianka Bhattacharya, Carroll Walter, Alex Parker, Christoph Lengauer, Alison Klein, Cristian Tomasetti, Elliot K. Fishman, Ralph H. Hruban, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

Original language	English (US)
Article number	eabb9601
Journal	Science
Volume	369
Issue number	6499
DOIs	https://doi.org/10.1126/science.abb9601
State	Published - Jul 3 2020

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Lennon, A. M., Buchanan, A. H., Kinde, I., Warren, A., Honushefsky, A., Cohain, A. T., Ledbetter, D. H., Sanfilippo, F., Sheridan, K., Rosica, D., Adonizio, C. S., Hwang, H. J., Lahouel, K., Cohen, J. D., Douville, C., Pate, A. A., Hagmann, L. N., Rolston, D. D., Malani, N., ... Papadopoulos, N. (2020). Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention. Science, 369(6499), Article eabb9601. https://doi.org/10.1126/science.abb9601

Lennon, AM, Buchanan, AH, Kinde, I, Warren, A, Honushefsky, A, Cohain, AT, Ledbetter, DH, Sanfilippo, F, Sheridan, K, Rosica, D, Adonizio, CS, Hwang, HJ, Lahouel, K, Cohen, JD, Douville, C, Pate, AA, Hagmann, LN, Rolston, DD, Malani, N, Zhou, S, Bettegowda, C, Diehl, DL, Urban, B, Still, CD, Kann, L, Woods, JI, Salvati, ZM, Vadakara, J, Leeming, R, Bhattacharya, P, Walter, C, Parker, A, Lengauer, C, Klein, A, Tomasetti, C, Fishman, EK, Hruban, RH, Kinzler, KW, Vogelstein, B & Papadopoulos, N 2020, 'Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention', Science, vol. 369, no. 6499, eabb9601. https://doi.org/10.1126/science.abb9601

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title = "Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention",

abstract = "Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.",

author = "Lennon, {Anne Marie} and Buchanan, {Adam H.} and Isaac Kinde and Andrew Warren and Ashley Honushefsky and Cohain, {Ariella T.} and Ledbetter, {David H.} and Fred Sanfilippo and Kathleen Sheridan and Dillenia Rosica and Adonizio, {Christian S.} and Hwang, {Hee Jung} and Kamel Lahouel and Cohen, {Joshua D.} and Christopher Douville and Pate, {Aalpen A.} and Hagmann, {Leonardo N.} and Rolston, {David D.} and Nirav Malani and Shibin Zhou and Chetan Bettegowda and Diehl, {David L.} and Bobbi Urban and Still, {Christopher D.} and Lisa Kann and Woods, {Julie I.} and Salvati, {Zachary M.} and Joseph Vadakara and Rosemary Leeming and Prianka Bhattacharya and Carroll Walter and Alex Parker and Christoph Lengauer and Alison Klein and Cristian Tomasetti and Fishman, {Elliot K.} and Hruban, {Ralph H.} and Kinzler, {Kenneth W.} and Bert Vogelstein and Nickolas Papadopoulos",

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AU - Buchanan, Adam H.

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AU - Warren, Andrew

AU - Honushefsky, Ashley

AU - Cohain, Ariella T.

AU - Ledbetter, David H.

AU - Sanfilippo, Fred

AU - Sheridan, Kathleen

AU - Rosica, Dillenia

AU - Adonizio, Christian S.

AU - Hwang, Hee Jung

AU - Lahouel, Kamel

AU - Cohen, Joshua D.

AU - Douville, Christopher

AU - Pate, Aalpen A.

AU - Hagmann, Leonardo N.

AU - Rolston, David D.

AU - Malani, Nirav

AU - Zhou, Shibin

AU - Bettegowda, Chetan

AU - Diehl, David L.

AU - Urban, Bobbi

AU - Still, Christopher D.

AU - Kann, Lisa

AU - Woods, Julie I.

AU - Salvati, Zachary M.

AU - Vadakara, Joseph

AU - Leeming, Rosemary

AU - Bhattacharya, Prianka

AU - Walter, Carroll

AU - Parker, Alex

AU - Lengauer, Christoph

AU - Klein, Alison

AU - Tomasetti, Cristian

AU - Fishman, Elliot K.

AU - Hruban, Ralph H.

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Papadopoulos, Nickolas

PY - 2020/7/3

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N2 - Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

AB - Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

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Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

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