Abstract
Background and Purpose - We sought to determine pedigree availability for a concordant sibling pair study of genetic risk factors in ischemic stroke. Methods - Probands with confirmed ischemic stroke were prospectively enrolled. Family histories were obtained by systematic interview. A study neurologist prospectively assigned stroke subtype. Results - Of 310 probands (median age, 75 years; range, 26 to 97 years; 48% women), 75% had at least 1 living sibling; 10%, at least 1 concordant living sibling; 2%, at least 1 concordant sibling living in the same city; and 7%, at least 1 concordant living and 1 discordant living sibling. Likelihood of having a concordant sibling increased significantly with proband age, even after adjustment for sibship size (P=0,002), Positive family history of stroke was not related to either proband stroke subtype or risk factor profile. Conclusions - Approximately 10 probands were screened to find 1 potentially concordant living sibling, A concordant sibling pair study should be multicentered and enable enrollment of siblings from diverse geographic areas.
Original language | English (US) |
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Pages (from-to) | 2939-2941 |
Number of pages | 3 |
Journal | Stroke |
Volume | 32 |
Issue number | 12 |
DOIs | |
State | Published - 2001 |
Keywords
- Cerebral infarction
- Feasibility studies
- Pedigree research
- Risk factors, genetic
- Stroke classification
- Stroke, ischemic
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing