Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography

Joline E. Brandenburg, Sarah F. Eby, Pengfei Song, Heng Zhao, Bradford W. Landry, Shirley Kingsley-Berg, William R. Bamlet, Shigao D Chen, Gary C Sieck, Kai Nan An

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives - The purpose of this study was to investigate the feasibility and reliability of passive muscle stiffness measurements in children by shear wave ultrasound elastography. Methods - We conducted a prospective cross-sectional study quantifying the passive stiffness of bilateral lateral gastrocnemius muscles during passive stretching in 20 typically developing children (age range, 2.0-12.6 years). Data collected included passive stiffness of the lateral gastrocnemius muscle (shear modulus in kilopascals) at 4 positions of progressive passive foot dorsiflexion, demographic characteristics of the participants, and comparison of demographic characteristics with the shear modulus. Results - Passive stiffness increased with increasing stretching (mean [SD] range of stiffness, 7.1 [2.0] to 36.2 [22.0] kPa). For all 4 foot positions, no significant difference was found between right and left legs (range, P = .42 to P = .98) or between the sexes (range, P = .28 to P >99). No correlation of passive muscle stiffness with age, body mass index, or ankle range of motion was found. The reliability of measurements was good to excellent (mean [95% confidence interval] range of reliability, 0.67 [0.44-0.83] to 0.80 [0.63-0.90]). Conclusions - Measurements of passive stiffness of the lateral gastrocnemius muscle are feasible and reliable in children as young as 2 years. Because this study found no significant difference between sex and the side tested in this age group, future studies involving children of this age range may not need to be stratified on the basis of these parameters. Defining normal passive muscle stiffness in children is critical for identifying and understanding the implications of abnormal passive muscle stiffness in children with neuromuscular disorders.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Elasticity Imaging Techniques
Muscles
Skeletal Muscle
Muscle Stretching Exercises
Demography
Articular Range of Motion
Ankle
Sex Characteristics
Ultrasonic Waves
Foot
Leg
Body Mass Index
Age Groups
Cross-Sectional Studies
Confidence Intervals

Keywords

  • Elastography
  • Feasibility
  • Gastrocnemius muscle
  • Pediatric ultrasound
  • Pediatrics
  • Skeletal muscle
  • Ultrasound elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography. / Brandenburg, Joline E.; Eby, Sarah F.; Song, Pengfei; Zhao, Heng; Landry, Bradford W.; Kingsley-Berg, Shirley; Bamlet, William R.; Chen, Shigao D; Sieck, Gary C; An, Kai Nan.

In: Journal of Ultrasound in Medicine, Vol. 34, No. 4, 01.04.2015, p. 663-670.

Research output: Contribution to journalArticle

Brandenburg, Joline E. ; Eby, Sarah F. ; Song, Pengfei ; Zhao, Heng ; Landry, Bradford W. ; Kingsley-Berg, Shirley ; Bamlet, William R. ; Chen, Shigao D ; Sieck, Gary C ; An, Kai Nan. / Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography. In: Journal of Ultrasound in Medicine. 2015 ; Vol. 34, No. 4. pp. 663-670.
@article{18b5204ac15f4191bf71387f5caebf12,
title = "Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography",
abstract = "Objectives - The purpose of this study was to investigate the feasibility and reliability of passive muscle stiffness measurements in children by shear wave ultrasound elastography. Methods - We conducted a prospective cross-sectional study quantifying the passive stiffness of bilateral lateral gastrocnemius muscles during passive stretching in 20 typically developing children (age range, 2.0-12.6 years). Data collected included passive stiffness of the lateral gastrocnemius muscle (shear modulus in kilopascals) at 4 positions of progressive passive foot dorsiflexion, demographic characteristics of the participants, and comparison of demographic characteristics with the shear modulus. Results - Passive stiffness increased with increasing stretching (mean [SD] range of stiffness, 7.1 [2.0] to 36.2 [22.0] kPa). For all 4 foot positions, no significant difference was found between right and left legs (range, P = .42 to P = .98) or between the sexes (range, P = .28 to P >99). No correlation of passive muscle stiffness with age, body mass index, or ankle range of motion was found. The reliability of measurements was good to excellent (mean [95{\%} confidence interval] range of reliability, 0.67 [0.44-0.83] to 0.80 [0.63-0.90]). Conclusions - Measurements of passive stiffness of the lateral gastrocnemius muscle are feasible and reliable in children as young as 2 years. Because this study found no significant difference between sex and the side tested in this age group, future studies involving children of this age range may not need to be stratified on the basis of these parameters. Defining normal passive muscle stiffness in children is critical for identifying and understanding the implications of abnormal passive muscle stiffness in children with neuromuscular disorders.",
keywords = "Elastography, Feasibility, Gastrocnemius muscle, Pediatric ultrasound, Pediatrics, Skeletal muscle, Ultrasound elastography",
author = "Brandenburg, {Joline E.} and Eby, {Sarah F.} and Pengfei Song and Heng Zhao and Landry, {Bradford W.} and Shirley Kingsley-Berg and Bamlet, {William R.} and Chen, {Shigao D} and Sieck, {Gary C} and An, {Kai Nan}",
year = "2015",
month = "4",
day = "1",
doi = "10.7863/ultra.34.4.663",
language = "English (US)",
volume = "34",
pages = "663--670",
journal = "Journal of Ultrasound in Medicine",
issn = "0278-4297",
publisher = "American Institute of Ultrasound in Medicine",
number = "4",

}

TY - JOUR

T1 - Feasibility and reliability of quantifying passive muscle stiffness in young children by using shear wave ultrasound elastography

AU - Brandenburg, Joline E.

AU - Eby, Sarah F.

AU - Song, Pengfei

AU - Zhao, Heng

AU - Landry, Bradford W.

AU - Kingsley-Berg, Shirley

AU - Bamlet, William R.

AU - Chen, Shigao D

AU - Sieck, Gary C

AU - An, Kai Nan

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Objectives - The purpose of this study was to investigate the feasibility and reliability of passive muscle stiffness measurements in children by shear wave ultrasound elastography. Methods - We conducted a prospective cross-sectional study quantifying the passive stiffness of bilateral lateral gastrocnemius muscles during passive stretching in 20 typically developing children (age range, 2.0-12.6 years). Data collected included passive stiffness of the lateral gastrocnemius muscle (shear modulus in kilopascals) at 4 positions of progressive passive foot dorsiflexion, demographic characteristics of the participants, and comparison of demographic characteristics with the shear modulus. Results - Passive stiffness increased with increasing stretching (mean [SD] range of stiffness, 7.1 [2.0] to 36.2 [22.0] kPa). For all 4 foot positions, no significant difference was found between right and left legs (range, P = .42 to P = .98) or between the sexes (range, P = .28 to P >99). No correlation of passive muscle stiffness with age, body mass index, or ankle range of motion was found. The reliability of measurements was good to excellent (mean [95% confidence interval] range of reliability, 0.67 [0.44-0.83] to 0.80 [0.63-0.90]). Conclusions - Measurements of passive stiffness of the lateral gastrocnemius muscle are feasible and reliable in children as young as 2 years. Because this study found no significant difference between sex and the side tested in this age group, future studies involving children of this age range may not need to be stratified on the basis of these parameters. Defining normal passive muscle stiffness in children is critical for identifying and understanding the implications of abnormal passive muscle stiffness in children with neuromuscular disorders.

AB - Objectives - The purpose of this study was to investigate the feasibility and reliability of passive muscle stiffness measurements in children by shear wave ultrasound elastography. Methods - We conducted a prospective cross-sectional study quantifying the passive stiffness of bilateral lateral gastrocnemius muscles during passive stretching in 20 typically developing children (age range, 2.0-12.6 years). Data collected included passive stiffness of the lateral gastrocnemius muscle (shear modulus in kilopascals) at 4 positions of progressive passive foot dorsiflexion, demographic characteristics of the participants, and comparison of demographic characteristics with the shear modulus. Results - Passive stiffness increased with increasing stretching (mean [SD] range of stiffness, 7.1 [2.0] to 36.2 [22.0] kPa). For all 4 foot positions, no significant difference was found between right and left legs (range, P = .42 to P = .98) or between the sexes (range, P = .28 to P >99). No correlation of passive muscle stiffness with age, body mass index, or ankle range of motion was found. The reliability of measurements was good to excellent (mean [95% confidence interval] range of reliability, 0.67 [0.44-0.83] to 0.80 [0.63-0.90]). Conclusions - Measurements of passive stiffness of the lateral gastrocnemius muscle are feasible and reliable in children as young as 2 years. Because this study found no significant difference between sex and the side tested in this age group, future studies involving children of this age range may not need to be stratified on the basis of these parameters. Defining normal passive muscle stiffness in children is critical for identifying and understanding the implications of abnormal passive muscle stiffness in children with neuromuscular disorders.

KW - Elastography

KW - Feasibility

KW - Gastrocnemius muscle

KW - Pediatric ultrasound

KW - Pediatrics

KW - Skeletal muscle

KW - Ultrasound elastography

UR - http://www.scopus.com/inward/record.url?scp=84925374771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925374771&partnerID=8YFLogxK

U2 - 10.7863/ultra.34.4.663

DO - 10.7863/ultra.34.4.663

M3 - Article

VL - 34

SP - 663

EP - 670

JO - Journal of Ultrasound in Medicine

JF - Journal of Ultrasound in Medicine

SN - 0278-4297

IS - 4

ER -