Feasibility and oncologic control after percutaneous image guided ablation of metastatic renal cell carcinoma

Brian T. Welch, Matthew R Callstrom, Jonathan M. Morris, Anil N. Kurup, Grant D. Schmit, Adam J. Weisbrod, Christine M. Lohse, Manish Kohli, Brian Costello, Kenneth R. Olivier, R. Houston Thompson, Stephen A. Boorjian, Thomas D. Atwell

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Abstract

Purpose We assessed the safety, local control and oncologic efficacy of percutaneous ablation in the treatment of metastatic renal cell carcinoma. Materials and Methods A retrospective review was performed of 61 patients who underwent 74 ablation procedures to treat 82 metastatic renal cell carcinoma lesions with the intent of local eradication. Technical success, local tumor control, complications and patient survival were analyzed according to standard criteria. Results Four (4.9%) technical failures were observed while 2 patients were lost to followup. Time to recurrence was assessed for the subset of 76 (93%) tumors that were followed after ablation. Six (of 76, 7.9%) tumors recurred at a mean of 1.6 years after ablation (median 1.4, range 0.6 to 2.9). Thus, known overall local tumor control was achieved in 70 of 80 (87.5%) tumors. Estimated local recurrence-free survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 94% (88-100, 41), 94% (88-100, 32) and 83% (70-97, 17), respectively. Estimated overall survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 87% (79-97, 42), 83% (73-94, 31) and 76% (63-90, 19), respectively. Conclusions Image guided ablation of metastatic renal cell carcinoma is a relatively safe procedure with acceptable local control rates. Ablation may offer patients a minimally invasive option of local tumor eradication and warrants a role in the multimodal treatment approach for select patients.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalJournal of Urology
Volume192
Issue number2
DOIs
StatePublished - 2014

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Renal Cell Carcinoma
Neoplasms
Survival Rate
Recurrence
Combined Modality Therapy
Safety
Survival

Keywords

  • ablation techniques
  • carcinoma
  • neoplasm metastasis
  • renal cell

ASJC Scopus subject areas

  • Urology

Cite this

Feasibility and oncologic control after percutaneous image guided ablation of metastatic renal cell carcinoma. / Welch, Brian T.; Callstrom, Matthew R; Morris, Jonathan M.; Kurup, Anil N.; Schmit, Grant D.; Weisbrod, Adam J.; Lohse, Christine M.; Kohli, Manish; Costello, Brian; Olivier, Kenneth R.; Thompson, R. Houston; Boorjian, Stephen A.; Atwell, Thomas D.

In: Journal of Urology, Vol. 192, No. 2, 2014, p. 357-363.

Research output: Contribution to journalArticle

Welch, BT, Callstrom, MR, Morris, JM, Kurup, AN, Schmit, GD, Weisbrod, AJ, Lohse, CM, Kohli, M, Costello, B, Olivier, KR, Thompson, RH, Boorjian, SA & Atwell, TD 2014, 'Feasibility and oncologic control after percutaneous image guided ablation of metastatic renal cell carcinoma', Journal of Urology, vol. 192, no. 2, pp. 357-363. https://doi.org/10.1016/j.juro.2014.03.006
Welch, Brian T. ; Callstrom, Matthew R ; Morris, Jonathan M. ; Kurup, Anil N. ; Schmit, Grant D. ; Weisbrod, Adam J. ; Lohse, Christine M. ; Kohli, Manish ; Costello, Brian ; Olivier, Kenneth R. ; Thompson, R. Houston ; Boorjian, Stephen A. ; Atwell, Thomas D. / Feasibility and oncologic control after percutaneous image guided ablation of metastatic renal cell carcinoma. In: Journal of Urology. 2014 ; Vol. 192, No. 2. pp. 357-363.
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abstract = "Purpose We assessed the safety, local control and oncologic efficacy of percutaneous ablation in the treatment of metastatic renal cell carcinoma. Materials and Methods A retrospective review was performed of 61 patients who underwent 74 ablation procedures to treat 82 metastatic renal cell carcinoma lesions with the intent of local eradication. Technical success, local tumor control, complications and patient survival were analyzed according to standard criteria. Results Four (4.9{\%}) technical failures were observed while 2 patients were lost to followup. Time to recurrence was assessed for the subset of 76 (93{\%}) tumors that were followed after ablation. Six (of 76, 7.9{\%}) tumors recurred at a mean of 1.6 years after ablation (median 1.4, range 0.6 to 2.9). Thus, known overall local tumor control was achieved in 70 of 80 (87.5{\%}) tumors. Estimated local recurrence-free survival rates (95{\%} CI, number still at risk) at 1, 2 and 3 years after ablation were 94{\%} (88-100, 41), 94{\%} (88-100, 32) and 83{\%} (70-97, 17), respectively. Estimated overall survival rates (95{\%} CI, number still at risk) at 1, 2 and 3 years after ablation were 87{\%} (79-97, 42), 83{\%} (73-94, 31) and 76{\%} (63-90, 19), respectively. Conclusions Image guided ablation of metastatic renal cell carcinoma is a relatively safe procedure with acceptable local control rates. Ablation may offer patients a minimally invasive option of local tumor eradication and warrants a role in the multimodal treatment approach for select patients.",
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T1 - Feasibility and oncologic control after percutaneous image guided ablation of metastatic renal cell carcinoma

AU - Welch, Brian T.

AU - Callstrom, Matthew R

AU - Morris, Jonathan M.

AU - Kurup, Anil N.

AU - Schmit, Grant D.

AU - Weisbrod, Adam J.

AU - Lohse, Christine M.

AU - Kohli, Manish

AU - Costello, Brian

AU - Olivier, Kenneth R.

AU - Thompson, R. Houston

AU - Boorjian, Stephen A.

AU - Atwell, Thomas D.

PY - 2014

Y1 - 2014

N2 - Purpose We assessed the safety, local control and oncologic efficacy of percutaneous ablation in the treatment of metastatic renal cell carcinoma. Materials and Methods A retrospective review was performed of 61 patients who underwent 74 ablation procedures to treat 82 metastatic renal cell carcinoma lesions with the intent of local eradication. Technical success, local tumor control, complications and patient survival were analyzed according to standard criteria. Results Four (4.9%) technical failures were observed while 2 patients were lost to followup. Time to recurrence was assessed for the subset of 76 (93%) tumors that were followed after ablation. Six (of 76, 7.9%) tumors recurred at a mean of 1.6 years after ablation (median 1.4, range 0.6 to 2.9). Thus, known overall local tumor control was achieved in 70 of 80 (87.5%) tumors. Estimated local recurrence-free survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 94% (88-100, 41), 94% (88-100, 32) and 83% (70-97, 17), respectively. Estimated overall survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 87% (79-97, 42), 83% (73-94, 31) and 76% (63-90, 19), respectively. Conclusions Image guided ablation of metastatic renal cell carcinoma is a relatively safe procedure with acceptable local control rates. Ablation may offer patients a minimally invasive option of local tumor eradication and warrants a role in the multimodal treatment approach for select patients.

AB - Purpose We assessed the safety, local control and oncologic efficacy of percutaneous ablation in the treatment of metastatic renal cell carcinoma. Materials and Methods A retrospective review was performed of 61 patients who underwent 74 ablation procedures to treat 82 metastatic renal cell carcinoma lesions with the intent of local eradication. Technical success, local tumor control, complications and patient survival were analyzed according to standard criteria. Results Four (4.9%) technical failures were observed while 2 patients were lost to followup. Time to recurrence was assessed for the subset of 76 (93%) tumors that were followed after ablation. Six (of 76, 7.9%) tumors recurred at a mean of 1.6 years after ablation (median 1.4, range 0.6 to 2.9). Thus, known overall local tumor control was achieved in 70 of 80 (87.5%) tumors. Estimated local recurrence-free survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 94% (88-100, 41), 94% (88-100, 32) and 83% (70-97, 17), respectively. Estimated overall survival rates (95% CI, number still at risk) at 1, 2 and 3 years after ablation were 87% (79-97, 42), 83% (73-94, 31) and 76% (63-90, 19), respectively. Conclusions Image guided ablation of metastatic renal cell carcinoma is a relatively safe procedure with acceptable local control rates. Ablation may offer patients a minimally invasive option of local tumor eradication and warrants a role in the multimodal treatment approach for select patients.

KW - ablation techniques

KW - carcinoma

KW - neoplasm metastasis

KW - renal cell

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