Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis

Vasculitis Clinical Research Consortium

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures. RESULTS: During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = -0.65) and with the mental component score (MCS; r = -0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS. CONCLUSION: Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.

Original languageEnglish (US)
Pages (from-to)928-934
Number of pages7
JournalThe Journal of rheumatology
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2019

Fingerprint

Systemic Vasculitis
Information Systems
Vasculitis
Patient Reported Outcome Measures
Feasibility Studies
Fatigue

Keywords

  • PATIENT-REPORTED OUTCOME MEASURES
  • VASCULITIS

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis. / Vasculitis Clinical Research Consortium.

In: The Journal of rheumatology, Vol. 46, No. 8, 01.08.2019, p. 928-934.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures. RESULTS: During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99{\%}) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = -0.65) and with the mental component score (MCS; r = -0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS. CONCLUSION: Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.",
keywords = "PATIENT-REPORTED OUTCOME MEASURES, VASCULITIS",
author = "{Vasculitis Clinical Research Consortium} and Gunnar Tomasson and Farrar, {John T.} and David Cuthbertson and McAlear, {Carol A.} and Susan Ashdown and Cronholm, {Peter F.} and Jill Dawson and Don Gebhart and Georgia Lanier and Luqmani, {Raashid A.} and Nataliya Milman and Jacqueline Peck and Robson, {Joanna C.} and Shea, {Judy A.} and Simon Carette and Nader Khalidi and Koening, {Curry L.} and Langford, {Carol A.} and Monach, {Paul A.} and Larry Moreland and Christian Pagnoux and Ulrich Specks and Sreih, {Antoine G.} and Ytterberg, {Steven R} and Merkel, {Peter A.}",
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T1 - Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis

AU - Vasculitis Clinical Research Consortium

AU - Tomasson, Gunnar

AU - Farrar, John T.

AU - Cuthbertson, David

AU - McAlear, Carol A.

AU - Ashdown, Susan

AU - Cronholm, Peter F.

AU - Dawson, Jill

AU - Gebhart, Don

AU - Lanier, Georgia

AU - Luqmani, Raashid A.

AU - Milman, Nataliya

AU - Peck, Jacqueline

AU - Robson, Joanna C.

AU - Shea, Judy A.

AU - Carette, Simon

AU - Khalidi, Nader

AU - Koening, Curry L.

AU - Langford, Carol A.

AU - Monach, Paul A.

AU - Moreland, Larry

AU - Pagnoux, Christian

AU - Specks, Ulrich

AU - Sreih, Antoine G.

AU - Ytterberg, Steven R

AU - Merkel, Peter A.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures. RESULTS: During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = -0.65) and with the mental component score (MCS; r = -0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS. CONCLUSION: Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.

AB - OBJECTIVE: The Patient Reported Outcome Measurement Information System (PROMIS) is a collection of item banks of self-reported health. This study assessed the feasibility and construct validity of using PROMIS instruments in vasculitis. METHODS: Data from a multicenter longitudinal cohort of subjects with systemic vasculitis were used. Instruments from 10 PROMIS item banks were selected with direct involvement of patients. Subjects completed PROMIS instruments using computer adaptive testing (CAT). The Medical Outcomes Study Short Form-36 (SF-36) was also administered. Cross-sectional construct validity was assessed by calculating correlations of PROMIS scores with SF-36 measures and physician and patient global scores for disease activity. Longitudinal construct validity was assessed by correlations of between-visit differences in PROMIS scores with differences in other measures. RESULTS: During the study period, 973 subjects came for 2306 study visits and the PROMIS collection was completed at 2276 (99%) of visits. The median time needed to complete each PROMIS instrument ranged from 40 to 55 s. PROMIS instruments correlated cross-sectionally with individual scales of the SF-36, most strongly with subscales of the SF-36 addressing the same domain as the PROMIS instrument. For example, PROMIS fatigue correlated with both the physical component score (PCS; r = -0.65) and with the mental component score (MCS; r = -0.54). PROMIS physical function correlated strongly with PCS (r = 0.81) but weakly with MCS (r = 0.29). Weaker correlations were observed longitudinally between change in PROMIS scores with change in PCS and MCS. CONCLUSION: Collection of data using CAT PROMIS instruments is feasible among patients with vasculitis and has some cross-sectional and longitudinal construct validity.

KW - PATIENT-REPORTED OUTCOME MEASURES

KW - VASCULITIS

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