Feasibility and clinical value of circulating tumor DNA testing in patients with gastric adenocarcinomas

Madiha Iqbal, Ali Roberts, Jason Starr, Kabir Mody, Pashtoon Murtaza Kasi

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Gastric cancer is one of the leading causes of cancer worldwide, and this trend appears to be rising. Most patients are diagnosed at an advanced stage and thus prognosis is poor. Liquid biopsy, or circulating tumor DNA (ctDNA) testing, is emerging as a promising prognostic and/or predictive biomarker for patients with various types of malignancies. Its value and utility for patients with gastrointestinal malignancies, particularly gastric cancer is still being explored. There is ongoing research in other tumor types to suggest that ctDNA testing can be potentially used to identify tumor specific genomic alterations, predict tumor mutation burden, as well as help assess clinical response. We report on the feasibility and clinical value of ctDNA testing in patients with gastric cancers in a real time clinical context by reporting data on cohort of patients with gastric cancers (including those with gastroesophageal junction adenocarcinomas) treated at our institution.

Original languageEnglish (US)
Pages (from-to)400-406
Number of pages7
JournalJournal of Gastrointestinal Oncology
Volume10
Issue number3
DOIs
StatePublished - 2019

Keywords

  • Biomarker
  • Circulating tumor DNA (ctDNA)
  • Gastric adenocarcinoma
  • Heterogeneity
  • Liquid biopsy

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Feasibility and clinical value of circulating tumor DNA testing in patients with gastric adenocarcinomas'. Together they form a unique fingerprint.

  • Cite this